New signing Nuno Valente is expected to make his Everton debut at home to Portsmouth.
Valente is needed to step in at left-back because of injuries to Alessandro Pistone and Gary Naysmith, with Phil Neville suspended.
New recruits Dario Silva and Salif Diao will make their Portsmouth debuts as Alain Perrin's side look for their first win of the season.
Fellow newcomer Zvonimir Vukic is also likely to feature for the first time.
Everton squad: Martyn, Hibbert, Yobo, Ferrari, Weir, Valente, Davies, Cahill, Arteta, Kilbane, Ferguson, Osman, Bent, McFadden, Wright, Vaughan, Li Tie, Wilson, Hughes.
Portsmouth: Westerveld, Priske, O'Brien, Stefanovic, Vignal, Vukic, Viafara, Diao, Robert, LuaLua, Silva, Ashdown, Griffin, O'Neil, Karadas, Mornar, Hughes, Taylor, Songo'o, Pericard, Todorov.
