It was another hard luck story for Martin O'Neill's demoralised Scottish champions in the Ukraine tonight as an emphatic Francelino Matuzalem double and exquisite Brandao chip in the second half left their European dreams in tatters.
Celtic's delight at seeing Bobo Balde recover from injury was rubbed by half-time with Jackie McNamara and Chris Sutton injured.
So it was no surprise that Martin O'Neill's men slumped to yet another away defeat in the Champions League to all but end their hopes of reaching the knock-out stages for another year.
With both sides pointless before tonight's clash in the Central Stadium, the defeat means Celtic are now bottom of Group F and in danger of missing out on a consolation UEFA Cup spot.
The wounded visitors went behind in the 56th minute when Matuzalem was given too much space to unleash a low shot which Marshall could only get the slightest of touches to as the ball flew into the back of his net.
Celtic's Champions League dream and even their hopes of a consolation place in the UEFA Cup were dealt what could be a fatal blow in the 62nd minute.
Matuzalem exchanged passes with Zvonimir Vukic and he emphatically fired the ball under Marshall to compound the visitors' misery.
It was no surprise that O'Neill took Juninho off and brought on Aiden McGeady - the only shock was that it took him so long with the disappointing Brazilian barely touching the ball.
But it was the home side who scored again when the Brazilian Brandao beat Marshall with over 12 minutes to go when he brilliantly dinked the ball over him and into the net.