Butt played in Macedonia in Saturday's 2-1 success but has an ongoing ankle problem and will not be fit for the game on his home ground.
Ferdinand missed the game in Skopje with a kidney complaint and it has not recovered sufficiently for him to be considered against the Group 7 whipping boys.
England had already lost the services of Manchester City winger Trevor Sinclair with a knee injury before the Macedonia game. But England coach Sven-Goran Eriksson has no plans to call up any replacement into his depleted squad at this stage.
He has already received a boost with the news that midfielder Steven Gerrard has shaken off the ankle problem which stopped him from being part of the side that overcame the Macedonians to be in contention to face Liechtenstein.
Filed by James Boylan
