Orlando Engelaar of PSV Eindhoven was one of four players to miss out as Netherlands boss Bert van Marwijk finalised his 23-man FIFA World Cup squad on Monday.
Along with Engelaar, Vurnon Anita, Ron Vlaar and Jeremain Lens will not travel to South Africa as the Netherlands bid to make a real impression in the tournament.
The Dutch open their World Cup campaign against Denmark on 14 June.
Netherlands World Cup squad:
Goalkeepers: Sander Boschker (FC Twente), Maarten Stekelenburg (Ajax), Michel Vorm (FC Utrecht)
Defenders: Khalid Boulahrouz (Stuttgart), Edson Braafheid (Celtic), John Heitinga (Everton), Joris Mathijsen (Hamburg), Andre Ooijer (PSV Eindhoven), Giovanni van Bronckhorst (Feyenoord), Gregory van der Wiel (Ajax)
Midfielders: Ibrahim Afellay (PSV Eindhoven), Nigel de Jong (Manchester City), Demy de Zeeuw (Ajax), Stijn Schaars (AZ Alkmaar), Wesley Sneijder (Inter Milan), Mark van Bommel (Bayern Munich), Rafael van der Vaart (Real Madrid)
Forwards: Ryan Babel (Liverpool), Eljero Elia (Hamburg), Klaas Jan Huntelaar (AC Milan), Dirk Kuyt (Liverpool), Arjen Robben (Bayern Munich), Robin van Persie (Arsenal)
