Leicester wing Gabriel Hamer-Webb will make his Wales debut in their Guinness Six Nations clash against Scotland.
Hamer-Webb is one of four changes from the side beaten heavily by France last weekend as Wales seek to end a sorry run of 13 straight Six Nations defeats.
Bath-born Hamer-Webb, who represented England Under-20s in the Six Nations, has made eight appearances for Leicester since moving from Cardiff last summer.
The 25-year-old qualifies for Wales through his Cardiff-born mother.
Hamer-Webb takes over from Scarlets wing Ellis Mee and Sam Costelow replaces Dan Edwards at outside-half.
Scarlets out-half Costelow has not played for Wales since the defeat to Japan at Kitakyushu in July.
There are two changes in the pack with Ben Carter preferred to Adam Beard in the second row and Taine Plumtree filling the blindside flanker spot.
Aaron Wainwright moves back to number eight, where he lined up for the opening defeat to England, and Olly Cracknell drops out.
Freddie Thomas, James Botham and Blair Murray are named on the bench for the first time in this Six Nations campaign.
Wales, who have lost 23 out of their previous 25 Tests, have not won a Six Nations home game since beating Scotland in February 2022.
Scotland arrive in Cardiff buoyed by a 31-20 Calcutta Cup victory over England that saw them bounce bounce from their opening Championship defeat to Italy.
Wales: L Rees-Zammit, G Hamer-Webb, E James, J Hawkins, J Adams, S Costelow, T Williams; R Carre, D Lake (capt), T Francis, D Jenkins, B Carter, T Plumtree, A Mann, A Wainwright.
Replacements: R Elias, N Smith, A Griffin, F Thomas, J Botham, K Hardy, J Evans, B Murray.
Watch England v Ireland in the Six Nations on Saturday from 1pm on RTÉ2 and RTÉ Player. Follow a live blog on the RTÉ News App and on rte.ie/sport. Listen to commentary on Saturday Sport on RTÉ Radio 1.
