Powerful young winger Henry Arundell will make his first test start for England against Ireland in their Six Nations finale in Dublin on Saturday, while Manu Tuilagi returns and Owen Farrell reclaims the out-half slot.
Arundell, 20, who has six caps as a replacement, comes in for Max Malins - who has scored two tries in 18 internationals - while centre Tuilagi makes his first appearance of the championship in place of the injured Ollie Lawrence.
Farrell replaces Marcus Smith, who drops to the bench.
That gives England the same Farrell-Tuilagi-Henry Slade combination that last started in the 2019 World Cup quarter-final victory over Australia as they seek to regain pride after the record 53-10 home defeat by France last week.
Ireland are chasing a fifth win for a Grand Slam and England are seeking to avoid losing three Six Nations games for the third year in a row.
Prop Dan Cole is in line to win his 100th cap from the bench.
"We know that after the bitter disappointment of the display against an exceptional France team last week, we will have to be much improved to meet the challenge of playing the side presently ranked number one in the world," Steve Borthwick said.
"However, I have witnessed an England squad determined to make amends for the defeat at Twickenham, and I am confident that the team announced today will once again want to show the sort of resilience and attitude that brought us victory in Wales."
Earlier, Ireland boss Andy Farrell named his team, which includes Caelan Doris, Dan Sheehan and Robbie Henshaw.
England: Freddie Steward; Anthony Watson, Henry Slade, Manu Tuilagi, Henry Arundell; Owen Farrell (capt), Jack van Poortvliet; Ellis Genge, Jamie George, Kyle Sinckler; Maro Itoje, David Ribbans; Lewis Ludlam, Jack Willis, Alex Dombrandt.
Replacements: Jack Walker, Mako Vunipola, Dan Cole, Nick Isiekwe, Ben Curry, Alex Mitchell, Marcus Smith, Joe Marchant.
Listen to the RTÉ Rugby podcast on Apple Podcasts, Soundcloud, Spotify or wherever you get your podcasts.
Watch Scotland v Italy in the Six Nations on Saturday from 12.30pm on RTÉ2 and RTÉ Player
Follow a live blog on Ireland v England on Saturday from 4pm on RTÉ.ie/sport and RTÉ News app and listen to live commentary on Saturday Sport on RTÉ Radio 1