Garry Ringrose has been ruled out of Ireland's Six Nations clash with Italy in Rome through injury, with Stuart McCloskey promoted into the starting team in his place.
Ringrose, who had been due to earn his 50th cap at the Stadio Olimpico, had been nursing a calf injury since the victory over France. Despite being initially named in the starting XV, he has now been withdrawn.
The Irish management have said they are hopeful that the Leinster centre will be fit for the remaining games of the Six Nations campaign, with Ireland chasing a fourth ever Grand Slam.
Ulster centre McCloskey will now start, slotting in at inside centre, while Bundee Aki moves to the outside centre berth.
Leinster utility back Jimmy O'Brien has been elevated to the bench.
Listen to the RTÉ Rugby podcast on Apple Podcasts, Soundcloud, Spotify or wherever you get your podcasts.
We need your consent to load this YouTube contentWe use YouTube to manage extra content that can set cookies on your device and collect data about your activity. Please review their details and accept them to load the content.Manage Preferences
Watch live coverage of Italy v Ireland (Saturday 2.15pm) on RTÉ2 and RTÉ Player, follow our live blog on RTÉ.ie/Sport and the RTÉ News app, or listen to live commentary on RTÉ Radio 1.
Watch live coverage of France v Scotland (Sunday, 3pm) on RTÉ2 and RTÉ Player.