Manu Tuilagi has been dropped by Steve Borthwick as the England head coach named a revamped side for their Guinness Six Nations opener against Scotland.
Tuilagi, a veteran of 50 caps and England regular when fit, has not even been named in Borthwick's first 23-man squad.
Joe Marchant takes the 31-year-old's place in the England line-up, with Marcus Smith and Owen Farrell to resume their playmaking axis for Saturday’s Calcutta Cup contest at Twickenham.
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Wing Ollie Hassell-Collins has been handed his first cap in a rejigged midfield following injuries to Elliot Daly, Henry Slade and Dan Kelly.
Ben Curry will be awarded his first cap against major opposition following his debut against the United States nearly two years ago.
Lewis Ludlam joins Curry as the other flanker, with Alex Dombrandt at No 8, while Jamie George starts at hooker after overcoming concussion sustained in Saracens’ defeat by Edinburgh on 22 January.
Borthwick said: "The England team that will play this weekend against Scotland have great experienced players and it also has exciting young talent and new combinations that will compliment that experience.
"The players are determined to represent their country with the fight that our supporters deserve and expect.
"There are a lot of players who have been fighting for an England opportunity for a period of time and now they have got their opportunity."
On Tuilagi’s omission, Borthwick added: "I am picking the team for this week and there are competition for places. There should be good players not in the 23 because we want depth in every position."
Munster's Ben Healy does not feature in Scotland's match-day squad, with Finn Russell starting at out-half and Blair Kinghorn named on the bench.
England: Freddie Steward; Max Malins, Joe Marchant, Owen Farrell (capt), Ollie Hassell-Collins; Marcus Smith, Jack van Poortvliet; Ellis Genge, Jamie George, Kyle Sinckler; Maro Itoje, Ollie Chessum; Lewis Ludlam, Ben Curry, Alex Dombrandt.
Replacements: Jack Walker, Mako Vunipola, Dan Cole, Nick Isiekwe, Ben Earl, Ben Youngs, Ollie Lawrence, Anthony Watson.
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