Wales full-back Leigh Halfpenny will make his first Test start for 19 months in Saturday's Six Nations opener against Ireland.
Halfpenny, who has won 97 caps, last featured in the starting line-up when Wales beat Canada in July 2021.
He is joined in the back three by Josh Adams and Rio Dyer, with George North partnered in midfield by Joe Hawkins, who wins his second cap.
Wales head coach Warren Gatland has selected six Ospreys forwards along with skipper Ken Owens and No 8 Taulupe Faletau.
Donal Lenihan and Eddie O'Sullivan expect a reaction from Wales under Warren Gatland when they face Ireland in Saturday's Six Nations opener
The Principality Stadium encounter kicks off Gatland’s second stint as Wales boss, with his previous reign between 2008 and 2019 yielding four Six Nations titles, three Grand Slams and two World Cup semi-finals.
Dan Biggar, who missed Wales' autumn Tests due to injury, is paired with Tomos Williams at half-back.
Alun Wyn Jones and Adam Beard are named in the second row with the in-form Jac Morgan selected at blindside flanker.
Rhys Webb is set for a first Wales appearance since November 2020 after being named among the replacements, where there are also impact roles for Exeter lock Dafydd Jenkins and Leicester flanker Tommy Reffell.
Gatland said: "We've picked Joe [Hawkins] at 12. He is a lovely footballer with some great skills. I thought for his first cap [against Australia in November] he was outstanding, so we have given him another opportunity.
"There is some real competition in the midfield at the moment, so I am really excited about that. There is a mixture in the team of some experience and some younger players. We were conscious as well picking the bench. We think we’ve got a bench that can come on and have an impact.
"Ireland are the No 1 team in the world, so they’re going to be coming here with a lot of confidence. You don’t become the No 1 team in the world without having some pretty consistent performances.
"We know how good they are and we are expecting a really tough contest. It’s important for us that we start well, but we need to be in the game at the last 20 minutes.
"We’ve only had a couple of weeks together, but I am confident that the guys will go out and give a good account of themselves."
Wales: Leigh Halfpenny; Josh Adams, George North, Joe Hawkins, Rio Dyer; Dan Biggar, Tomos Williams; Gareth Thomas, Ken Owens (capt), Tomas Francis; Adam Beard, Alun Wyn Jones; Jac Morgan, Justin Tipuric, Taulupe Faletau.
Replacements: Scott Baldwin, Rhys Carre, Dillon Lewis, Dafydd Jenkins, Tommy Reffell, Owen Williams, Alex Cuthbert.
Follow every game of the Guinness Six Nations on RTÉ.ie/Sport and the RTÉ News app, or listen to live commentary on RTÉ Radio 1.
Watch live television coverage of Ireland v France (11 February), Italy v Ireland (25 February) and Scotland v Ireland (12 March) on RTÉ2 and RTÉ Player.
