Wing Liam Williams and number eight Josh Navidi have been included in the Wales starting lineup to face England in their Guinness Six Nations clash at Twickenham on Saturday (4.45pm), as the pair make a first appearance in 2020 after returning from injury.
Williams replaces the injured Josh Adams, who has been ruled out of the remainder of the tournament with an ankle injury, while Navidi comes in for Taulupe Faletau, who drops to the bench.
Coach Wayne Pivac has made four changes in all, restoring Tomos Williams at scrum-half and bolstering the front row with prop Rob Evans following the 27-23 home defeat to France last time out.
"Liam's return to full fitness is a positive after the loss of Josh (Adams), as is the return of Josh Navidi," Pivac said.
"We have been targeting this game for both of their returns and they have trained really well so it's a great opportunity for them on Saturday.
"We have had the chance to put the disappointments of the loss to France behind us and we know heading to London we need to be more clinical in attack and convert the opportunities that we are creating."
Dan Biggar will continue in the fly-half berth, while George North has been picked on the wing after he suffered a concussion against the French.
It means the centre partnership remains unchanged with Hadleigh Parkes alongside former England junior international Nick Tompkins.
Wales must beat England to stand any chance of retaining the Six Nations crown they won in 2019 under former coach Warren Gatland.
They have lost on their last four visits to Twickenham, with their previous success coming in a 28-25 victory in 2015.
Wales: L Halfpenny (Scarlets); G North (Ospreys), N Tompkins (Saracens), H Parkes (Scarlets), L Williams (Scarlets); D Biggar (Northampton), T Williams (Cardiff Blues); R Evans (Scarlets), K Owens (Scarlets), D Lewis (Cardiff Blues), J Ball (Scarlets), A W Jones (Ospreys, capt), R Moriarty (Dragons), J Tipuric (Ospreys), J Navidi (Cardiff Blues).
Replacements: R Elias (Scarlets), R Carre (Saracens), L Brown (Dragons), A Shingler (Scarlets), T Faletau (Bath), R Webb (Bath), J Evans (Cardiff Blues), J McNicholl (Scarlets).