Fly-half Camille Lopez has been ruled out of France's final Six Nations match against England at Twickenham on Saturday (5pm, live on RTÉ2) through injury, the team said in a statement.
Lopez has been told to rest for between four and six weeks. He was replaced at half-time during the 29-0 win over Italy in Rome on Sunday, although the team have not specified the nature of his injury.
Maxime Machenaud has been called up to the squad in his place.