Wales were dealt a second major injury blow on Friday with the news that prop Samson Lee will miss the Six Nation clash against Scotland at Murrayfield.
Lee has joined wing George North on the sidelines, missing a game that the Welsh must win to keep alive their title hopes.
Lee suffered a knock to his head during last week's Millennium Stadium defeat against England and was unable to complete the final component of graduated return to play protocols.
Ospreys tighthead Aaron Jarvis has replaced Lee in the starting line-up, with Cardiff Blues forward Scott Andrews named among Wales' replacements.
Lee's loss comes after it was decided earlier this week to rest North for the Edinburgh trip.
North has been given an extended recovery period by Wales and he will not be involved in the Murrayfield encounter.
He took two heavy blows to his head during the England game, and although the Welsh Rugby Union has consistently said he has been symptom-free in terms of concussion, he is now spending time recovering.
North, 22, was concussed when Wales lost to world champions New Zealand last November and he sat out the following weekend's Millennium Stadium appointment with South Africa.
Rugby union's world governing body World Rugby said earlier this week that North should not have remained on the field against England after a clash of heads with team-mate Richard Hibbard.
But World Rugby added that it accepted the WRU's explanation surrounding the incident.
North appeared to suffer a momentary loss of consciousness following the 61st-minute collision with Hibbard. WRU national medical manager Prav Mathema subsequently admitted that had the second incident been seen by medics, then North would have been immediately taken off and replaced.
