Uncapped 21-year-old Wasps flanker James Haskell has been included in a 28-man England squad for the RBS 6 Nations clash with France on Sunday week.
Gloucester full-back Olly Morgan has been ruled out with a shoulder injury.
With Morgan and his Gloucester colleague Iain Balshaw (groin) out of the running, Wasps' Josh Lewsey could find himself at full-back against France, with Jason Robinson - if fit - Mark Cueto and David Strettle challenging for the wing berths.
Robinson, who scored three tries in England's Six Nations victories over Scotland and Italy, missed out at Croke Park because of a neck problem sustained during training.
However, he has been advised that surgery is not required and Ashton will be keeping his fingers crossed he is fit for selection.
Strettle, meanwhile, answered a late call to replace Robinson and delivered an outstanding Test debut display, scoring England's solitary try in a record 43-13 defeat.
Ashton said: 'I will be monitoring the progress from their injuries of Jason Robinson and Magnus Lund, and wish Olly Morgan, who is seeing a specialist today, a speedy recovery from his shoulder injury.'
Ashton, who is due to name his starting line-up next Tuesday, will look closely at the effectiveness of centre partnership Mike Tindall and Andy Farrell, but it is up front where England were exposed by a rampant Irish pack.
Changes in every row of the scrum cannot be ruled out, with prop Julian White, lock Tom Palmer, flanker Tom Rees and the recalled Borthwick all presenting strong selection cases.
England, despite their Dublin debacle, remain in the title shake-up, but defeat to France - a country they have not beaten since the 2003 World Cup semi-final triumph in Sydney - would render those hopes redundant.
England's 28-man squad for the RBS 6 Nations Championship game against France at Twickenham on 11 March:
Backs: J Lewsey (Wasps), J Robinson (Sale Sharks), M Cueto (Sale Sharks), D Strettle (Harlequins), M Tait (Newcastle), M Tindall (Gloucester), A Farrell (Saracens), M Catt (London Irish), J Wilkinson (Newcastle), T Flood (Newcastle), H Ellis (Leicester), S Perry (Bristol).
Forwards: P Freshwater (Perpignan), P Vickery (Wasps, capt), J White (Leicester), T Payne (Wasps), G Chuter (Leicester), L Mears (Bath), L Deacon (Leicester), D Grewcock (Bath), S Borthwick (Bath), T Palmer (Wasps), N Easter (Harlequins), J Worsley (Wasps), J Haskell (Wasps), M Lund (Sale Sharks), T Rees (Wasps), M Corry (Leicester).
