Connacht welcome back Bundee Aki for the visit of a depleted Munster at the Dexcom Stadium on Saturday (7.45pm), while backrow Alex Kendellen is set to become the visitors' youngest ever centurion.
Irish international Aki missed the recent tour of South Africa, while Finlay Bealham is named among the replacements for the penultimate game of the season.
Out-half Josh Ioane returns, partnered at half-back by Ben Murphy, while Sam Gilbert partners Aki at centre.
Cian Prendergast captains the side in a backrow that also contains Shamus Hurley-Langton, Sean Jansen.
Munster are shorn a number of frontline players. Victory over Ulster last time out came at a cost, with Jack Crowley, Tadhg Beirne, Jean Kleyn, Tom Farrell, Oli Jager and Calvin Nash ruled out.
JJ Hanrahan and Craig Casey is the half-back pairing, with Mike Haley, Shane Daly and Andrew Smith making up the back three.
Jeremy Loughman, Diarmuid Barron and the returning Michael Ala'alatoa start in the front row, with Fineen Wycherley and Edwin Edogbo packing down in the second row.
Thomas Ahern, John Hodnett and Gavin Coombes complete the side in the backrow, with 25-year-old Alex Kendellen poised to become Munster’s youngest ever centurion if he comes off the replacements bench.
Connacht: Sam Gilbert, Shane Jennings, Harry West, Bundee Aki, Shayne Bolton, Josh Ioane, Ben Murphy; Billy Bohan, Dylan Tierney-Martin, Sam Illo, Darragh Murray, Josh Murphy, Cian Prendergast (C), Shamus Hurley-Langton, Sean Jansen
Replacements: Eoin de Buitléar, Peter Dooley, Finlay Bealham, Joe Joyce, Paul Boyle, Matthew Devine, Jack Carty, Seán Naughton
Munster Rugby: Mike Haley; Shane Daly, Alex Nankivell, Dan Kelly, Andrew Smith; JJ Hanrahan, Craig Casey (C); Jeremy Loughman, Diarmuid Barron, Michael Ala’alatoa; Edwin Edogbo, Fineen Wycherley; Tom Ahern, John Hodnett, Gavin Coombes.
Replacements: Lee Barron, Josh Wycherley, Conor Bartley, Jack O’Donoghue, Brian Gleeson, Ben O’Donovan, Seán O’Brien, Alex Kendellen.
In the aftermath of Leinster's Champions Cup semi-final win over Toulon, head coach Leo Cullen has rotated his squad for Saturday’s URC meeting with the Lions (5.30pm) at Aviva Stadium.
James Ryan captains the side, partnered by Brian Deeny with Thomas Clarkson, John McKee and Ed Byrne packing down at the coalface and Max Deegan, Will Connors and James Culhane making up the backrow.
Sam Prendergast and Luke McGrath is the new half-back pairing, with Jamie Osborne and Rieko Ioane in midfield.
Ciarán Frawley takes the 15 jersey with Joshua Kenny and Jimmy O’Brien on the wings.
Leinster: Ciarán Frawley, Joshua Kenny, Rieko Ioane, Jamie Osborne, Jimmy O’Brien, Sam Prendergast, Luke McGrath ; Ed Byrne, John McKee, Thomas Clarkson, Brian Deeny, James Ryan (C), Max Deegan, Will Connors, James Culhane
Replacements: Dan Sheehan, Andrew Porter, Rabah Slimani, Diarmuid Mangan, Scott Penny, Fintan Gunne, Hugh Cooney, Hugo Keenan
