Dan Sheehan will captain Leinster when they host Sale Sharks in the quarter-finals of the Investec Champions Cup at Aviva Stadium on Saturday evening.
Alex Usanov will make his first European start after a debut off the bench last week against Edinburgh.
James Ryan returns to Leo Cullen's side from injury to cover the second row, alongside Joe McCarthy.
Jack Conan takes over at number eight, with Ryan Baird at blindside flanker and Josh van der Flier at openside flanker.
Usanov and Tadhg Furlong will scrum down either side of Sheehan.
Hugo Keenan continues at full-back, Rieko Ioane moves to the wing, with Tommy O'Brien on the opposite side.Jamie
Osborne continues at 12, with Garry Ringrose returning from injury to join him at centre.
Jamison Gibson-Park and Harry Byrne are named as the half-backs.
Rónan Kelleher, Jerry Cahir and Thomas Clarkson are the front-row cover, while Max Deegan and Scott Penny complete the forward reinforcements. Luke McGrath, Ciarán Frawley, and Robbie Henshaw complete the matchday 23.
Leinster: Hugo Keenan: Tommy O'Brien, Garry Ringrose, Jamie Osborne, Rieko Ioane; Harry Byrne, Jamison Gibson-Park; Alex Usanov, Dan Sheehan (captain), Tadhg Furlong; Joe McCarthy, James Ryan; Ryan Baird, Josh van der Flier, Jack Conan.
Replacements: Rónan Kelleher, Jerry Cahir, Thomas Clarkson, Max Deegan, Scott Penny, Luke McGrath, Ciarán Frawley, Robbie Henshaw.
Connacht Stauart Lancaster has made four personnel changes from the team that defeated the Sharks last week for the trip to Occitania to face Montpellier in the quarter-finals of the EPCR Challenge Cup.
Three of those are enforced, with the injured Dave Heffernan, Josh Ioane and Shane Jennings replaced by Dylan Tierney-Martin, Sean Naughton, and Shayne Bolton. The latter makes his first appearance in over three months after recovering from injury.
The final change is in the back row, with Paul Boyle coming in at number eight and Josh Murphy set to make an impact off the bench.
The pack is completed by props Billy Bohan and Sam Illo, locks Joe Joyce and Darragh Murray, and the in-form Shamus Hurley-Langton.
In the backs, Matthew Devine continues at scrum-half, Bundee Aki and Cathal Forde continue together at centre, and the back three is completed by winger Chay Mullins and full-back Sam Gilbert.
Finlay Bealham is unavailable due to personal reasons, with Jack Aungier named among the replacements.
Cian Prendergast captains the team from blindside flanker, in what will be his 100th appearance for the province.
Connacht: Sam Gilbert: Shayne Bolton, Cathal Forde, Bundee Aki, Chay Mullins; Sean Naughton, Matthew Devine; Billy Bohan, Dylan Tierney-Martin, Sam Illo; Joe Joyce, Darragh Murray; Cian Prendergast (captain), Shamus Hurley-Langton, Paul Boyle.
Replacements: Matthew Victory, Peter Dooley, Jack Aungier, Josh Murphy, Sean O'Brien, Ben Murphy, Jack Carty, John Devine.
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