Caelan Doris will make his return from injury against New Zealand on Saturday (8.10pm) in Chicago, with the Leinster number 8 named on the bench by head coach Andy Farrell.
Doris hasn't played since suffering a shoulder injury in early May, which ruled him out of the British and Irish Lions tour of Australia, but is included for Saturday’s game at Soldier Field.
Leinster hooker Dan Sheehan will captain the team, one of 11 in the starting XV who featured on this summer’s Lions tour.
It will be Sheehan's second time captaining Ireland, after he filled in for Doris in the Six Nations win against Wales in Cardiff earlier this year.
As expected, Jack Crowley has been rewarded for his excellent start to the season with a start at out-half, getting the nod over Sam Prendergast who is among the replacements.
Stuart McCloskey has earned a start in the centre, with the Ulster man preferred to Bundee Aki and Robbie Henshaw.
Leinster's Paddy McCarthy (above) is in line for his debut, with the 22-year-old named among the replacements.
Farrell has stuck with his first-choice front row of Sheehan, Andrew Porter and Tadhg Furlong, after the trio started together in the second and third Lions Tests in Australia.
James Ryan partners Tadhg Beirne at lock, with Iain Henderson set for his first Ireland appearance since the opening round of the Six Nations off the bench.
Jack Conan will pack down at number 8, having started all three Lions Tests, with Josh van der Flier named on the openside flank. Ryan Baird has won the race to start at blindside flanker.
Jamison Gibson-Park is paired with Crowley in the half-backs, with McCloskey and Garry Ringrose the preferred centre combination.
With Mack Hansen ruled out due to injury, Tommy O'Brien is picked on the right wing. The 27-year-old scored four tries in his first two caps against Georgia and Portugal this summer.
James Lowe starts against his native New Zealand on the left, while Jamie Osborne fills in at full-back as expected, in the absence of Hugo Keenan.
McCarthy will make his debut off the bench, joined by otherwise experienced front row options in Rónan Kelleher and Finlay Bealham.
Craig Casey, Prendergast and Aki are the backline replacements.
Ireland: Jamie Osborne; Tommy O’Brien, Garry Ringrose, Stuart McCloskey, James Lowe; Jack Crowley, Jamison Gibson-Park; Andrew Porter, Dan Sheehan, Tadhg Furlong; James Ryan, Tadhg Beirne; Ryan Baird, Josh van der Flier, Jack Conan.
Replacements: Rónan Kelleher, Paddy McCarthy, Finlay Bealham, Iain Henderson, Caelan Doris, Craig Casey, Sam Prendergast, Bundee Aki.
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