Ireland got their Rugby World Cup campaign up and running with an excellent victory over Japan last weekend.
Scott Bemand's side scored six tries in a 42-14 win over the Sakura XV.
They know a similar result will see them safely into the quarter-finals with a game to spare.
Spain, beaten 54-8 by New Zealand in the first round, stand in their way at Franklin's Gardens on Sunday afternoon.
Find out all you need to know about the match here.
TV
Ireland v Spain will be live on RTÉ2 and RTÉ Player, with coverage getting under way at 11.30am.
New Zealand v Japan follows after on the same channels, with a kick-off time of 2pm.
USA v Australia (Saturday, 7.30pm) is also live on RTÉ2 and RTÉ Player.
RADIO
The game is live on RTÉ Radio 1 Extra, with Michael Corcoran joined by Sharon Lynch.
ONLINE
There will be a live blog on www.rte.ie/sport and the RTÉ News app, as well as match report, reaction and a special RTÉ Rugby podcast recapping the game.
Listen to the RTÉ Rugby podcast on Apple Podcasts, Spotify or wherever you get your podcasts.
Ireland will have taken a lot of confidence and comfort from the manner of their victory over Japan last weekend.
The fast start they had targeted was achieved and although they had to weather a lively storm from their opponents after racing into a 21-0 lead, they were relatively comfortable across the 80 minutes and came through the contest unscathed.
This game, the 12th between the sides, comes too soon for Aoife Wafer, who has joined up with the squad and continues to rehab her injured knee.
But Bemand has rung the changes, making a notable seven switches from the side that ran out last weekend.
Clíodhna Moloney-MacDonald, Ellena Perry, Eimear Corri-Fallon, Claire Boles and Grace Moore all come into the pack, with co-captain Edel McMahon rested following her successful return from injury against the Sakura.
Molly Scuffil-McCabe and Anna McGann replace Aoibheann Reilly and Béibhinn Parsons in the backs as the head coach manages the squad workload ahead of what he hopes will be a Pool C decider against the Black Ferns in eight days' time in Brighton.
Spain, meanwhile, have made a total of nine changes to the side beaten in round one with captain Lourdes Alameda the only forward to retain her place.
Coach Juan Gonzalez Marruecos has also brought in backs Claudia Cano and Claudia Perez.
While Ireland did account for Spain in the WXV3 two years ago, there will still be some hurt in the camp from the infamous 8-7 loss in Parma in 2021, a result that sent the team's World Cup qualifying hopes spiralling.
However, there's enough water under the bridge for this game to take a life of its own and if Ireland can reproduce the discipline and patience displayed against Japan, they'll be in the quarter-finals and have a free shot against the world champions on 7 September.
TEAMS
Ireland: Stacey Flood; Anna McGann, Aoife Dalton, Eve Higgins, Amee-Leigh Costigan; Dannah O'Brien, Molly Scuffil-McCabe; Ellena Perry, Clíodhna Moloney-MacDonald, Linda Djougang; Eimear Corri-Fallon, Sam Monaghan (co-captain); Fiona Tuite, Claire Boles, Grace Moore.
Replacements: Neve Jones, Siobhán McCarthy, Sadhbh McGrath, Ruth Campbell, Brittany Hogan, Emily Lane, Enya Breen, Nancy McGillivray.
Spain: Amalia Argudo; Claudia Perez, Claudia Pena, Claudia Cano, Clara Piquero; Zahia Perez, Anne Fernandez de Corres; Gemma Silva, Marieta Roman, Eider Garcia; Lourdes Alameda (capt), Elena Martinez, Lia Pineiro, Ana Peralta, Valentina Perez.
Replacements: Cristina Blanco, Laura Delgado, Mireia de Andres, Anna Puig, Monica Castelo, Nerea Garcia, Bingbing Vergara, Lea Ducher.
OFFICIALS
Referee: Kat Roche
Assistant Referees: Clara Munarini, Amber Stamp-Dunstan
TV Match Official: Matteo Liperini
WHAT THEY SAID
Scott Bemand (Ireland head coach): "This is our first chance to nail that quarter-final position. We're absolutely gunning for it. We've been gunning for it in training which is why it's important that people have the opportunity to be allowed to compete for this position."
Juan Gonzalez Marruecos (Spain head coach): "[Ireland] are a team that have developed a lot since we played them in WXV two years ago. You can see how much they have improved as they recently beat New Zealand. We know they're a tough team, it will be a really good challenge."
PREVIOUS MEETINGS
Ireland 15-13 Spain (28 October 2023, WXV3, Dubai)
Ireland 7-8 Spain (13 September 2021, World Cup qualifying, Parma)
Ireland 41-7 Spain (17 May 2008, European Championships, Amsterdam)
Ireland 25-10 Spain (4 February 2006, Six Nations, Donnybrook)
Spain 19-17 Ireland (5 February 2005, Six Nations, Madrid)
Watch Ireland v Spain in the Rugby World Cup on Sunday from 11.30am on RTÉ2 and RTÉ Player. Follow a live blog on rte.ie/sport and the RTÉ News app. Listen to live radio commentary on RTÉ Radio 1 Extra
