After a frustrating defeat to Italy in Dublin two weeks ago, Ireland head to Cork where Wales are the visitors.
Scott Bemand's side are still looking for a first championship victory since 2022.
Find out all you need to know about the game here.
ONLINE
Follow a live blog on rte.ie/sport and the RTÉ News app.
RADIO
Listen to commentary on Saturday Sport on RTÉ Radio 1.
TV
The game is live on Virgin Media Two. Scotland v England (Saturday, 2.15pm) is live on RTÉ Player.
WEATHER
It will be partly cloudy in Cork late on Saturday afternoon with temperatures set to be about 12C.
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Ireland meet Wales for the 23rd time in the championship looking for a first victory over the visitors since 2021's 45-0 win at the Cardiff Arms Park, a game that seems a lifetime ago.
However, Clíodhna Moloney's recall to the squad means that there are nine players from that 23 remaining for Saturday's game.
Ireland began their campaign with a respectable 38-17 defeat in France and followed that up with a poor loss to Italy, 27-21, in round two at the RDS.
The hosts dominated for large spells but execution and composure at certain times cost them.
Wales, meanwhile, were beaten by Scotland in Cardiff in their opening fixture, losing 20-18. Ioan Cunningham's side conceded eight tries in a 46-10 loss to England last time out.
Moloney's inclusion means the Exeter player is in line for a first cap since 2021.
Bemand makes just one change to his starting XV with co-captain Edel McMahon returning to the flank instead of Grace Moore, while Ealing Trailfinders lock / back row Shannon Ikahihifo is in line for a first cap off the bench.
Jasmine Joyce returns on the wing, Sisilia Tuipulotu starts at tighthead, Alisha Butchers is at blindside, while Keira Bevan is at scrum-half.
TEAMS
Ireland: Lauren Delany; Katie Corrigan, Eve Higgins, Enya Breen, Béibhinn Parsons; Dannah O'Brien, Aoibheann Reilly; Linda Djougang, Neve Jones, Christy Haney; Dorothy Wall, Sam Monaghan (co-capt); Aoife Wafer, Edel McMahon (co-capt), Brittany Hogan.
Replacements: Clíodhna Moloney, Niamh O'Dowd, Sadhbh McGrath, Fiona Tuite, Shannon Ikahihifo, Molly Scuffil-McCabe, Nicole Fowley, Aoife Dalton.
Wales: Jenny Hesketh; Jasmine Joyce, Hannah Jones (capt), Kerin Lake, Carys Cox; Lleucu George, Keira Bevan; Gwenllian Pyrs, Carys Phillips, Sisilia Tuipulotu; Abbie Fleming, Georgia Evans; Alisha Butchers, Alex Callender, Bethan Lewis.
Replacements: Molly Reardon, Abbey Constable, Donna Rose, Natalia John, Gwennan Hopkins, Sian Jones, Kayleigh Powell, Courtney Keight.
OFFICIALS
Referee: Sara Cox (RFU)
AR 1: Aurelie Groizeleau (FFR)
AR 2: Chelsea Gillespie (SRU)
TMO: Andrew McMenemy (SRU)
WHAT THEY SAID
Scott Bemand (Ireland head coach): "This game is another opportunity for us to perform in front of our home support. We want to get the tide of support and noise behind us. The hard work has gone in and now we're ready to go after that winning performance."
Ioan Cunningham (Wales head coach): "The week without a game has been valuable for us as we have had the opportunity to analyse our performances and assess that honestly and constructively.
"We've focused on working hard, especially so on a few aspects we'll have to strengthen against the Irish – but also on a lot of positive things we've done in the first two games."
LAST 5 SIX NATIONS MEETINGS
2023: Wales 31-5 Ireland, Cardiff Arms Park
2022: Ireland 19-27 Wales, RDS Arena
2021: Wales 0-45 Ireland, Cardiff Arms Park
2020: Ireland 31-12 Wales, Energia Park
2019: Wales 24-5 Ireland, Cardiff Arms Park
Elsewhere, Scotland host England at 2.15pm on Saturday afternoon, while Italy are in France for a 12.30pm kick-off on Sunday.
You can see a full list of results, fixtures and standings here.
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