Katie Corrigan will make her Ireland debut against France in Saturday's Guinness Women’s Six Nations opener, while Sevens players Béibhinn Parsons and Eve Higgins are in the starting XV.
Corrigan is selected on the wing for her first cap, with the 19-year-old having impressed head coach Scott Bemand during the recent Celtic Challenge competition.
Edel McMahon will captain the side from the back row, as co-captain Sam Monaghan is continuing her return-to-play protocols.
Corrigan is joined in the back three by Lauren Delany at full-back with Parsons (below) on the other wing.
Nicole Fowley starts at out-half, marking her return to the Championship for the first time since 2019.
Fowley made her international comeback in October for the WXV3 series in Dubai against Kazakhstan.
Aoife Dalton and Higgins make up the centre pairing.
Molly Scuffil-McCabe, Dannah O’Brien and Méabh Deely provide the backline reinforcements on the bench.
Up front, Linda Djougang, Neve Jones and Christy Haney make up the front row, with Dorothy Wall and Hannah O’Connor in the second row.
McMahon is joined in the backrow by Aoife Wafer and Brittany Hogan.
Sarah Delaney, Niamh O’Dowd, Sadhbh McGrath, Fiona Tuite and Grace Moore give Bemand strong options from the bench.
"We are all very excited to get our Guinness Women’s Six Nations campaign under way and we come into this weekend ready to put a confident performance out there," said Bemand.
"We have had a good block of preparation with players returning and we are ready to compete.
"I’m looking forward to seeing all the hard work come together on Saturday and what a place to kick start our Six Nations, in Stade Marie-Marvingt."
France: Emilie Boulard; Kelly Arbey, Nassira Konde, Gabrielle Vernier, Marine Menager; Lina Queyroi, Pauline Bourdon Sansus; Annaelle Deshaye, Agathe Sochat, Assia Khalfaoui; Manae Feleu (capt), Madoussou Fall; Charlotte Escudero, Gaelle Hermet, Romane Menager
Replacements: Elisa Riffonneau, Ambre Mwayembe, Clara Joyeux, Kiara Zago, Emeline Gros, Alexandra Chambon, Lina Tuy, Morgane Bourgeois
Ireland: Lauren Delany; Katie Corrigan, Eve Higgins, Aoife Dalton, Béibhinn Parsons; Nicole Fowley, Aoibheann Reilly; Linda Djougang, Neve Jones, Christy Haney; Dorothy Wall, Hannah O'Connor; Aoife Wafer, Edel McMahon (capt), Brittany Hogan.
Replacements: Sarah Delaney, Niamh O’Dowd, Sadhbh McGrath, Fiona Tuite, Grace Moore, Molly Scuffil-McCabe, Dannah O’Brien, Méabh Deely.
Watch France v Ireland in the Women's Six Nations on Saturday from 1.45pm on RTÉ2 and RTÉ Player, follow a live blog on rte.ie/sport and the RTÉ News app and listen to Saturday Sport on RTÉ Radio 1