Munster will be without Peter O'Mahony once again for Sunday's Investec Champions Cup Pool 3 meeting with Exeter at Sandy Park.
The flanker hasn't recovered in time from a shoulder injury which he suffered in his side's BKT URC win against the Stormers last month.
Head coach Graham Rowntree has made six changes from their disappointing 17-17 draw against Bayonne last week, as they look to get their pool campaign back on track against the 2020 champions.
There's an interesting selection in the forwards where Gavin Coombes moves in from number 8 to the second row, while Tom Ahern is retained at blindside flanker for the fourth game in a row.
Jack O'Donoghue comes into the starting team at the base of the scrum, with hooker Diarmuid Barron and tighthead prop Stephen Archer the other changes in the pack.
Jeremy Loughman, Tadhg Beirne, and John Hodnett retain their places in the side, with Beirne captaining the province for the second game in a row.
In the backline, Craig Casey is preferred to Conor Murray at scrum-half and links up with Jack Crowley in the half-backs.
Antoine Frisch returns to the centre in place of Rory Scannell where he joins Alex Nankivell, while Shane Daly is fit to start at full-back, allowing Calvin Nash move back to the wing.
Seán O'Brien has come through his return to play protocols and starts on the left wing.
Munster: Shane Daly; Calvin Nash, Antoine Frisch, Alex Nankivell, Seán O'Brien; Jack Crowley, Craig Casey; Jeremy Loughman, Diarmuid Barron, Stephen Archer; Gavin Coombes, Tadhg Beirne (C); Tom Ahern, John Hodnett, Jack O’Donoghue.
Replacements: Eoghan Clarke, Josh Wycherley, Oli Jager, Brian Gleeson, Alex Kendellen, Conor Murray, Rory Scannell, Ben O’Connor.
The Leinster team to face Sale Sharks sees Thomas Clarkson (above) make his European debut, having been part of the matchday squad against La Rochelle.
Garry Ringrose and James Ryan co-captain the team once more.
Ringrose, who will make his 50th European appearance at the RDS tomorrow, is joined by Robbie Henshaw in the centre, with Ciarán Frawley and Jamison Gibson-Park completing the backline. Frawley starts at out-half for the first time in European competition, having come off the bench last Sunday.
In the pack, Clarkson joins the experienced duo of Andrew Porter and Dan Sheehan in the front row for his European debut.
Jason Jenkins starts this weekend having come off the bench in Stade Marcel Deflandre last Sunday and partners Ryan in the second row.
Josh van der Flier comes into the back row in the final change to the pack, where he joins Ryan Baird and Caelan Doris.
Among the replacements, half-backs Ben Murphy and Sam Prendergast are in line to make their Champions Cup debuts. Murphy was part of last weekend's squad in France, while Prendergast features in a Champions Cup squad for the first time.
Leinster: Hugo Keenan; Jordan Larmour, Garry Ringrose (co-capt), Robbie Henshaw, Jimmy O’Brien; Ciarán Frawley, Jamison Gibson-Park; Andrew Porter, Dan Sheehan, Thomas Clarkson; Jason Jenkins, James Ryan (co-capt); Ryan Baird, Josh van der Flier, Caelan Doris.
Replacements: Rónan Kelleher, Cian Healy, Michael Ala'alatoa, Joe McCarthy, Jack Conan, Ben Murphy, Sam Prendergast, Charlie Ngatai.
Mack Hansen will miss Connacht's Pool 1 meeting with Saracens at the StoneX Stadium, but captain Jack Carty will make his 200th appearance for the province.
Carty returns as one of nine changes, with head coach Pete Wilkins ringing the changes after his side's heavy defeat to Bordeaux a week ago.
Hansen is ruled out due to a foot injury picked up in the first half of that 41-5 defeat, with John Porch taking his place at full-back.
Carty comes in at out-half having sat out the Bordeaux loss, and will become the sixth player to reach the 200 cap milestone for the province, after John Muldoon, Michael Swift, Denis Buckley, Kieran Marmion and Tiernan O'Halloran.
Bundee Aki stays in the centre, with Tom Farrell coming in for Cathal Forde, while Byron Ralston and Shayne Bolton are on the wings, with Bolton set for his first game of the season.
There's also a first game of the season at second row for Gavin Thornbury who partners Darragh Murray at lock.
Dave Heffernan is retained at second row, but Wilkins has changed his props with Jordan Duggan and Jack Aungier starting.
Cian Prendergast continues at blindside flanker, while Paul Boyle and Conor Oliver come in to complete the side.
Connacht: John Porch; Byron Ralston, Tom Farrell, Bundee Aki, Shayne Bolton; Jack Carty (capt), Caolin Blade; Jordan Duggan, Dave Heffernan, Jack Aunger; Darragh Murray, Gavin Thornbury; Cian Prendergast, Conor Oliver, Paul Boyle.
Replacements: Dylan Tierney-Martin, Denis Buckley, Finlay Bealham, Joe Joyce, Jarrad Butler, Michael McDonald, JJ Hanrahan, Diarmuid Kilgallen.
Ireland international lock Iain Henderson (above) will captain Ulster as they face Racing 92 on Saturday.
Henderson is joined by fellow stalwart, Alan O'Connor, in the second row.
World-Cup winning Springbok Steven Kitshoff, makes his European home debut against Racing 92, where he will face his South Africa team-mate and captain, Siya Kolisi.
Joining Kitshoff in the front row is Rob Herring at hooker, who returns to the starting line-up, and Tom O’Toole, who retains his place at tighthead prop.
In the back row, Dave Ewers, who won the Champions Cup in 2020 with Exeter Chiefs, retains his place at blindside flanker and is joined by Nick Timoney at openside flanker. Matty Rea, gets the nod at eight to complete the back-row.
John Cooney returns to the starting line-up at scrum-half and is joined by Billy Burns at out-half, with Burns overcoming an elbow injury to start.
Jacob Stockdale and Rob Baloucoune retain their places on the left and right wing respectively.
Stuart McCloskey and James Hume will continue their centre partnership in the back-field and Mike Lowry starts at full-back, after returning from injury.
Ulster: Mike Lowry; Rob Baloucoune, James Hume, Stuart McCloskey, Jacob Stockdale; Billy Burns, John Cooney; Steven Kitshoff, Rob Herring, Tom O'Toole; Alan O'Connor, Iain Henderson (capt); Dave Ewers, Nick Timoney, Matty Rea.
Replacements: Tom Stewart, Eric O’Sullivan, Marty Moore, Kieran Treadwell, Harry Sheridan, Nathan Doak, Jake Flannery, Stewart Moore.
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Watch Leinster v Sale Sharks in the Champions Cup on Saturday from 4.45pm on RTÉ2 and RTÉ Player, follow a live blog on www.rte.ie/sport and the RTÉ News app.
