Ireland have been forced to make two late changes to their squad ahead of their Six Nations opener with Wales, with Jamison Gibson-Park and Cian Healy ruled out through injury.

The Leinster scrum half was initially named to start and trained with the team yesterday, but has been pulled from the side on the morning of the game due to a hamstring issue.

Conor Murray comes into the starting XV to replace Gibson-Park, with the Munster scrum-half last featuring for Ireland on his 100th cap against South Africa in November, before a groin injury saw him miss the following two games. Craig Casey has been elevated to the replacements' bench, where he will wear the number 21 shirt.

Injury has also seen Cian Healy withdraw from the squad. The Leinster prop had been named among the replacements, but also appears to have fallen to a hamstring injury, with Dave Kilcoyne promoted to the bench in his place.

Andy Farrell's side was already hit by the injury to prop Tadhg Furlong during the week.

The Six Nations' favourites are seeking a first Six Nations victory in the Welsh capital since 2013.

Follow our live blog of Wales v Ireland (Saturday 2.15pm) on RTÉ.ie/Sport and the RTÉ News app, or listen to live commentary on RTÉ Radio 1.

Watch live coverage of England v Scotland (Saturday 4.45pm) on RTÉ2 and RTÉ Player.

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