Leinster lock Jason Jenkins has been rewarded for his excellent early season form with a recall to the Springboks squad set to face Ireland next Saturday in the first of their November Tests.
Such is the world champions' strength up front that head coach Jacques Nienaber and director of rugby Rassie Erasmus have been able to 'rest' Ulster number eight Duane Vermeulen for the four-Test tour.
South Africa have included uncapped fly-halves Manie Libbok and Sacha Feinberg-Mngomezulu in their squad for next month's autumn international series, and electric winger Cheslin Kolbe returns after recovering from injury.
The Springboks will play four tests, starting against Ireland in Dublin on 5 November, followed by matches on consecutive Saturdays against France, Italy and England.
The Boks face a mini-crisis at fly-half with regular first choice Handre Pollard injured, Elton Jantjies unavailable for selection and the experienced Frans Steyn also on the treatment table.
But the Stormers pair of Libbock and Feinberg-Mngomezulu have shown excellent form in the United Rugby Championship.
Feinberg-Mngomezulu, 20, who also holds a British passport, is a reported target for England coach Eddie Jones so is likely to be capped on tour by the Boks at some stage to ward off that attention.
"Manie and Sacha have shown what they are capable of at United Rugby Championship and Junior Springbok level," Bok coach Nienaber said in a media release from South African Rugby.
"We are facing three of the top five teams in the world in Ireland, France and England, and we are building our squad for the World Cup next year at the same time, so it was important to maintain consistency in selection while also rewarding a few talented young players."
Injuries to key players have "granted us an opportunity to see what the next generation of players can do," he added.
But Lukanyo Am has not recovered in time, meaning there are three specialist centres on tour in Damian de Allende, Andre Esterhuizen and Jesse Kriel.
Damian Willemse can also cover in that position, but is expected to start at fly-half after an impressive Rugby Championship in that position.
South Africa have also selected an 'A' squad that will take on Munster and Bristol Bears in midweek games.
This will be a selection made up from players in the main Bok squad and some notable other names, including fly-half Johan Goosen, centre Cornal Hendricks and scrum-half Herschel Jantjies.
South Africa squad for European Tour
Forwards: Thomas du Toit, Steven Kitshoff, Vincent Koch, Frans Malherbe, Ox Nche, Trevor Nyakane, Malcolm Marx, Bongi Mbonambi, Lood de Jager, Eben Etzebeth, Jason Jenkins, Salmaan Moerat, Marvin Orie, Pieter-Steph du Toit, Siya Kolisi, Evan Roos, Kwagga Smith, Marco van Staden, Jasper Wiese, Deon Fourie, Franco Mostert.
Backs: Faf de Klerk, Jaden Hendrikse, Cobus Reinach, Manie Libbok, Damian Willemse, Damian de Allende, Andre Esterhuizen, Jesse Kriel, Willie le Roux, Makazole Mapimpi, Sbu Nkosi, Kurt-Lee Arendse, Cheslin Kolbe, Sacha Feinberg-Mngomezulu.
