Chris Cosgrave will make just his second Leinster start when Leo Cullen's charges travel to Wales to face Scarlets in the BKT United Rugby Championship on Friday night.
Cosgrave and fellow academy graduate Rob Russell will have the steady hand of Dave Kearney to guide them in the back three.
In the centre, Charlie Ngatai is joined by Liam Turner, with Ireland internationals Luke McGrath and Ross Byrne the half-backs.
Ed Byrne, John McKee and Thomas Clarkson line up in the front row, with McKee and Clarkson making their first starts of the season.
Ross Molony and Jason Jenkins are selected in the second row, with Rhys Ruddock back as captain. Scott Penny and Max Deegan complete the pack.
On the bench, Tadgh McElroy Charlie Tector and Ben Brownlee could all potentially make their debuts for the province.
Leinster: Chris Cosgrave, Rob Russell, Liam Turner, Charlie Ngatai, Dave Kearney, Ross Byrne, Luke McGrath, Ed Byrne, John McKee, Thomas Clarkson, Ross Molony, Jason Jenkins, Rhys Ruddock (captain), Scott Penny, Max Deegan
Replacements: Tadgh McElroy, Michael Milne, Vakhtang Abdaladze, Brian Deeny, Martin Moloney, Nick McCarthy, Charlie Tector, Ben Brownlee
Watch Munster v Ulster in the United Rugby Championship on Saturday from 4.45pm on RTÉ2 and RTÉ Player, listen to live commentary on RTÉ Radio 1 and follow a live blog on RTÉ.ie/sport and RTÉ News app.
Watch Ospreys v Connacht in the United Rugby Championship on Saturday from 7.30pm on RTÉ2 and RTÉ Player.
