Ireland were overwhelmed by a professional England outfit who remain on target for a TikTok Women's Six Nations Grand Slam.
Simon Middleton’s charges ran in 11 tries in total but were restricted to just two in an opening half where Ireland’s defence stood firm, for the most part, in front of a record home crowd of 15,836 at Welford Road.
Recalled centre Sene Naoupu was sent off with 12 minutes to play, while flanker Dorothy Wall had been sin-binned earlier in the second half.
Scotland are Ireland’s final opponents with that match taking place in Belfast on Saturday night with England heading to France looking for a clean sweep.
Shorn of almost an entire backline due to sevens commitments and also without forwards Sam Monaghan and Aoife Wafer, Ireland were always going to be up against it. The hosts' winning run now extends to 22 Tests.
Hooker Lark Davies was at the end of a maul after just two minutes to get the scoring under way but the visitors held England out for the next 15 minutes thanks to some superb defending with Neve Jones, Edel McMahon and Naoupu all intervening to frustrate the Red Roses.
But Ireland's inability to secure set-piece ball was always handing England attacking platforms and Sarah Bern, again from a lineout maul grabbed their second.
Ireland could have reduced the margin to just a score in the 23rd minute but Nicole Cronin screwed a penalty under the posts wide after a rare spell of possession in the opposition 22.
Cronin was replaced by Michelle Claffey after half an hour but Ireland continued to hold out and Eimear Considine and debutant Molly Scuffil-McCabe coming up with big defensive plays.
Captain Nichola Fryday may have felt that England should have had Leanne Infante sin-binned when the scrum-half pushed Claffey in the face but referee Amber McLachlan decided a penalty reversal was the correct sanction.
Getting in with just two tries against was a victory of sorts for Greg McWilliams’ side who had to make do with just 16% territory in the half.
Ireland won nine penalties during that period with sharp play at the breakdown forcing England into a series of mistakes.
But England, who had already beaten Scotland, Italy and Wales, didn’t take long to add to their tally after the break.
Player of the match Marlie Packer crossed just two minutes in before Ireland were reduced to 14 when Dorothy Wall was sin-binned for a high tackle on Jess Breach, who went off for a HIA.
That proved an expensive mistake by the Ireland flanker with England, through Davies, Lydia Thompson and Poppy Cleall, scoring three tries in the next ten minutes.
Hannah Botterman bashed over for another as Ireland lost Considine to a nasty leg injury, which will likely rule her out of next weekend’s match in Belfast.
The tries continued to rain down as Ireland’s amateur players tired and Cleall and Ellie Kildunne finished off moves.
Naoupu, who was featuring in her first game of the campaign, was red-carded in the 68th minute for a high tackle on Emily Scarratt, who, on her 100th cap, needed a HIA.
Thompson finished the scoring with three minutes left, leaving England to look forward to a Grand Slam decider against Les Bleues next weekend.
"I'm thrilled with how we came out of this game," said Middleton.
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England: Helena Rowland; Lydia Thompson, Emily Scarratt, Holly Aitchison, Jessica Breach; Zoe Harrison, Leanne Infante; Vickii Cornborough, Lark Davies, Sarah Bern; Zoe Aldcroft, Abbie Ward; Alex Matthews, Marlie Packer, Sarah Hunter (capt).
Replacements: Amy Cokayne, Hannah Botterman, Maud Muir, Rosie Galligan, Poppy Cleall, Natasha Hunt, Amber Reed, Ellie Kildunne.
Ireland: Molly Scuffil-McCabe; Aoife Doyle, Sene Naoupu, Enya Breen, Eimear Considine; Nicole Cronin, Kathryn Dane; Linda Djougang, Neve Jones, Christy Haney, Nichola Fryday (capt), Aoife McDermott; Dorothy Wall, Edel McMahon, Hannah O'Connor.
Replacements: Emma Hooban, Chloe Pearse, Katie O'Dwyer, Grace Moore, Maeve Óg O’Leary, Aoibheann Reilly, Michelle Claffey, Niamh Byrne.