Manu Tuilagi and Luke Cowan-Dickie are missing from England's training squad for their three-day camp in Bristol this week.
Tuilagi is recovering from a hamstring strain and Cowan-Dickie is being monitored for a knee injury incurred in Saturday’s Guinness Six Nations win over Wales.
Tom Curry is overcoming the concussion sustained at Twickenham in Round 3 so Lewis Ludlow has been called up as back-row cover.
Alongside Tuilagi, Jonny Hill has been unable to take part in this Six Nations because of a high ankle stress fracture but the Exeter lock is to continue his rehab with England.
Uncapped London Irish prop Will Goodrick-Clarke has been included, but Elliot Daly and George Ford are omitted from the 25-man squad who will begin preparations for the clash with Ireland on 12 March.
Eddie Jones has opted to keep Marcus Smith as the only specialist fly-half in camp, so Ford will be present to direct Leicester in Saturday’s match against Saracens.
Daly, meanwhile, has failed to leave his mark at outside centre and so Joe Marchant will be given another chance after being parachuted on to the bench against Wales once Tuilagi had been ruled out.
England 25-man training squad:
Forwards: A Barbeary (Wasps), J Blamire (Newcastle Falcons), A Dombrandt (Harlequins), C Ewels (Bath Rugby), E Genge (Leicester Tigers), J George (Saracens), W Goodrick-Clarke (London Irish), M Itoje (Saracens), N Isiekwe (Saracens), J Launchbury (Wasps), C Lawes (Northampton Saints), L Ludlow (Gloucester Rugby), S Simmonds (Exeter Chiefs), K Sinckler (Bristol Bears), W Stuart (Bath Rugby).
Backs: G Furbank (Northampton Saints), O Hassell-Collins (London Irish), M Malins (Saracens), J Marchant (Harlequins), J Nowell (Exeter Chiefs), H Randall (Bristol Bears), H Slade (Exeter Chiefs), M Smith (Harlequins), F Steward (Leicester Tigers), B Youngs (Leicester Tigers).
Listen to the RTÉ Rugby podcast on Apple Podcasts, Soundcloud, Spotify or wherever you get your podcasts.
Follow all of Ireland's Six Nations games via our live blogs on rte.ie/sport and on the RTÉ News App or listen to live radio coverage on RTÉ Radio 1. Watch live coverage of England v Ireland on Saturday 12 March (4.45pm) on RTÉ2 and RTÉ Player.
Also, see live URC action this week with Ulster v Cardiff (Friday 4 March, 7pm) and Benetton v Leinster (Saturday 5 March, 12.30pm) live on RTÉ2 and RTÉ Player.
