Manu Tuilagi has been ruled out of England's Guinness Six Nations clash against Wales with a hamstring injury.
Tuilagi had been due to make his first start in the competition in almost two years after completing his recovery from a torn hamstring.
However, England revealed late on Thursday that a scan had uncovered a "low grade" issue.
Joe Marchant has been recalled and will train with the squad on Friday, while an updated team will be confirmed on Saturday.
Tuilagi was due to make his first start in the competition in almost two years after completing his recovery from a torn hamstring.
Wales boss Wayne Pivac has left out wing Louis Rees-Zammit and recalled number eight Taulupe Faletau for Saturday's game.
Rees-Zammit is replaced by a fit-again Josh Adams, with Alex Cuthbert retained on the other wing and set to win his 50th cap.
Faletau makes his first Wales appearance for 11 months, having proved his fitness following a long-term ankle injury by playing in Bath's last two Gallagher Premiership matches against Wasps and Leicester.
He returns in a reshaped back-row, with Ross Moriarty switching to blindside flanker and Taine Basham lining up at openside. Jac Morgan, who made his Test debut against Scotland 12 days ago, is on the bench.
Pivac has retained Owen Watkin and Nick Tompkins as his centre combination, while there are call-ups among the replacements for Ospreys fly-half Gareth Anscombe, Scarlets scrum-half Kieran Hardy and Dragons prop Leon Brown.
Players with English clubs are released back to them if they are not involved in a Wales matchday 23, so Gloucester star Rees-Zammit will be available for the Premiership appointment with Leicester on Saturday.
He is one of the most exciting players in European rugby, collecting four tries during last season's Six Nations and being picked for the British and Irish Lions' South Africa tour.
The 21-year-old has carved out a reputation for scoring dazzling solo tries, which he underlined with a breathtaking touchdown against Fiji during this season's Autumn Nations Series.
But Cuthbert shone against Scotland, while Adams, who missed that game due to a calf muscle problem, has repeatedly excelled for Wales, with 17 tries in 36 Tests.
Wales: Liam Williams; Alex Cuthbert, Owen Watkin, Nick Tompkins, Josh Adams; Dan Biggar (capt), Tomos Williams; Wyn Jones, Ryan Elias, Tomas Francis, Adam Beard, Will Rowlands, Ross Moriarty, Taine Basham, Taulupe Faletau
Replacements: Dewi Lake, Gareth Thomas, Leon Brown, Seb Davies, Jac Morgan, Kieran Hardy, Gareth Anscombe, Jonathan Davies.
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Follow all of Ireland's Six Nations games via our live blogs on rte.ie/sport and on the RTÉ News App or listen to live radio coverage on RTÉ Radio 1. Watch live coverage of Connacht v Stormers (12.30) and England v Wales on Saturday 26 Feb (4pm) on RTÉ2 and RTÉ Player. Highlights on Against the Head, Mondays, 8pm.
