Dave Kearney will make his first appearance of the season for Leinster when they take on Edinburgh Rugby at the RDS Arena on Friday evening.
Leo Cullen is able to recall Kearney on the left wing for his 170th appearance in the blue shirt.
He's joined in the back three by full-back Jamie Osborne and Tommy O'Brien.
Nick McCarthy gets his first start since returning from Munster in the summer and will partner Ross Byrne in the half-backs.
Sitting outside them in midfield are Ciarán Frawley and Rory O'Loughlin.
Cullen has switched up half of his pack with four changes from those who started the loss to Cardiff last time out.
James Tracy replaces Seán Cronin in the front row with Ed Byrne and Michael Ala'alatoa retaining their spots either side of him.
Ross Molony and Josh Murphy come into the second row while Max Deegan is the sole change in the back row.
Deegan will wear the number eight shirt with Scott Penny swapping to the openside. Rhys Ruddock fills the last spot in the XV and will captain the side.
Seán Cronin, Peter Dooley, Vakh Abdaladze, Devin Toner, Martin Moloney, Luke McGrath, Harry Byrne and Rob Russell make up the bench.
Leinster team: Jamie Osborne, Tommy O'Brien, Rory O'Loughlin, Ciarán Frawley, Dave Kearney, Ross Byrne, Nick McCarthy, Ed Byrne, James Tracy, Michael Ala'alatoa, Ross Molony, Josh Murphy, Rhys Ruddock (captain), Scott Penny, Max Deegan.
Replacements: Seán Cronin, Peter Dooley, Vakh Abdaladze, Devin Toner, Martin Moloney, Luke McGrath, Harry Byrne, Rob Russell
Watch Leinster v Edinburgh (Friday 6pm) on RTÉ2 and the RTÉ Player.
Simon Zebo (above) will make his 150th appearance for Munster in tomorrow night's URC visit to the Glasgow Warriors.
The province's record tryscorer is one of eight changes from the side that registered a bonus point win away to Zebre last time out.
Zebo starts on the left wing with Shane Daly swapping over to the right, and Mike Haley coming in at full-back.
It's a new centre partnership, with Chris Farrell and Rory Scannell drafted in as Munster continue to operate in the absence of Damian de Allende who remains sidelined with a hip and groin injury, with no return marked out by management.
Neil Cronin continues at scrum-half, while Ben Healy takes the 10 shirt, as Jack Crowley continues in his role on the replacements bench.
The pack has a more settled look, with just one change coming in the front five, as the experience of Stephen Archer is drafted in at the expense of Keynan Knox at tighthead.
Johann van Graan has also been able to avail of Gavin Coombes at number eight after he was released from Irish camp, while Chris Cloete comes in for John Hodnett at openside flanker.
Hodnett is set to feature off the bench, with Munster taking a 6:2 split in their replacements.
Munster Rugby: Mike Haley; Shane Daly, Chris Farrell, Rory Scannell, Simon Zebo; Ben Healy, Neil Cronin; Jeremy Loughman, Diarmuid Barron, Stephen Archer; Jean Kleyn, Fineen Wycherley; Jack O'Donoghue (capt), Chris Cloete, Gavin Coombes.
Replacements: Kevin O'Byrne, Josh Wycherley, John Ryan, Cian Hurley, Alex Kendellen, Paddy Patterson, Jack Crowley, John Hodnett.
