Bundee Aki will partner Robbie Henshaw at centre for the British and Irish Lions series decider against South Africa.
Warren Gatland reacted to their second Test defeat by making six changes including a revamped back three featuring Liam Williams and Josh Adams.
Stuart Hogg and Anthony Watson have made way for the Welsh duo whose aerial expertise will be essential to hopes of winning Saturday's series decider at Cape Town Stadium, but in a surprise move, Duhan Van Der Merwe keeps his place.
Dan Biggar continues at out-half but he is rejoined at half-back by Ali Price in a repeat of the partnership that started the first Test. Conor Murray drops to the bench.
Chris Harris is jettisoned at outside centre to make way for Aki’s promotion into the starting XV, with Henshaw sliding to 13.
Tadhg Beirne, who was a late replacement in the first two Tests, drops out of the matchday squad with Adam Beard providing back-up at lock.
Gatland has performed major surgery to his front row in expectation of a renewed set-piece assault from South Africa by bringing in prop Wyn Jones, who has recovered from a shoulder issue, and hooker Ken Owens.
The second and back rows remain unchanged, meaning Alun Wyn Jones continues as captain to make his 12th consecutive Test appearance for the Lions.
Gatland has also made adjustments to the bench, where England captain Owen Farrell loses out to Finn Russell, who has recovered from an Achilles injury.
Kyle Sinckler is named among the replacements after his citing for an alleged bite was dismissed.
All the momentum is with South Africa after they emerged conclusive 27-9 winners from a fractious clash at Cape Town Stadium on Saturday, levelling the series at 1-1.
But Gatland said: "The matchday 23 have an incredibly special opportunity in front of them – to seal a Lions series victory in South Africa.
"It doesn’t get much bigger than this and we’re excited by the challenge that faces us on Saturday.
"We’ve no excuses from last week, the Springboks put us under pressure in the second half and deserved the win. We have to be much better than that second-half performance, and I believe we will be."
South Africa have made two enforced changes after scrum-half Faf de Klerk and flanker Pieter-Steph du Toit were ruled out due to injury.
British and Irish Lions: 15 Liam Williams (Scarlets, Wales), 14 Josh Adams (Cardiff, Wales), 13 Robbie Henshaw (Leinster, Ireland), 12 Bundee Aki (Connacht, Ireland), 11 Duhan van der Merwe (Worcester Warriors, Scotland), 10 Dan Biggar (Northampton Saints, Wales), 9 Ali Price (Glasgow Warriors, Scotland); 1 Wyn Jones (Scarlets, Wales), 2 Ken Owens (Scarlets, Wales), 3 Tadhg Furlong (Leinster, Ireland), 4 Maro Itoje (Saracens, England), 5 Alun Wyn Jones (capt) (Ospreys, Wales), 6 Courtney Lawes (Northampton Saints, England), 7 Tom Curry (Sale Sharks, England), 8 Jack Conan (Leinster, Ireland).
Replacements: 16 Luke Cowan-Dickie (Exeter Chiefs, England), 17 Mako Vunipola (Saracens, England), 18 Kyle Sinckler (Bristol Bears, England), 19 Adam Beard (Ospreys, Wales), 20 Sam Simmonds (Exeter Chiefs, England), 21 Conor Murray (Munster, Ireland), 22 Finn Russell (Racing 92, Scotland), 23 Elliot Daly (Saracens, England).
Follow South Africa v Lions third Test with our live blog on RTÉ.ie/sport and the RTÉ News app or listen to live commentary with Donal Lenihan and Michael Corcoran on RTÉ's 2fm from 4.45pm Saturday.