Conor Murray will make his first start since being named Alun Wyn Jones' replacement as British and Irish Lions captain in Wednesday’s clash with South Africa 'A’, with Ireland team-mates Bundee Aki and Iain Henderson also named in the side.
Murray is reunited with Dan Biggar at half-back at Cape Town Stadium in a combination that was last seen in the 28-10 victory over Japan that launched the tour in Edinburgh last month.
Murray played 29 minutes as a replacement against the Sharks at Loftus Versfeld on Saturday in his second appearance of the tour, his afternoon cut short by a yellow card for killing the ball.
There are only three survivors from the XV that overwhelmed the team from Natal, with Biggar, Anthony Watson and Chris Harris retaining their places.
Watson makes successive starts and switches from wing to full-back to form a back three with Welsh duo Louis Rees-Zammit and Josh Adams. Harris moves from inside to outside centre, with Aki taking the number 12 jersey.
Warren Gatland has opted for a back row of Josh Navidi, Tom Curry and Taulupe Faletau as the Lions await their toughest test of the tour having amassed a total of 181 points in three games against provincial opposition.
"We're pleased to have arrived in Cape Town as we near the halfway stage of the series," said Gatland.
"Wednesday’s game against South Africa 'A’ will be our toughest encounter since we arrived here and we’re looking forward to it. We expect them to be physical in the contact area and look to test us at scrum time.
"I think we’ve benefitted from playing at altitude in the first three games. While the boys have felt it in their lungs, they’ll be all the better for it now we’re at sea level.
"As we move towards the business end of the tour, it’s pleasing to see so many players putting in some standout performances. As coaches we want the players to make Test selection as hard as possible and that's we’re seeing."
Meanwhile, Faf De Klerk and Cheslin Kolbe are among the players included in a strong South Africa 'A' team.
Lukhanyo Am skippers a side that features nine men who played in the Springboks’ 2019 World Cup final victory over England.
Five players retain starting places from the 40-9 win against Georgia on 2 July in Willie Le Roux, Pieter-Steph Du Toit, Franco Mostert, Eben Etzebeth and Trevor Nyakane.
The experienced figure of Morne Steyn has also been named in the team by coach Jacques Nienaber.
The second Test against Georgia that was scheduled for last Friday was cancelled because of coronavirus infections in both camps.
While it then emerged at the weekend that a fresh group of South Africa players and staff, including captain Siya Kolisi, had tested positive, a significant proportion of the squad were able to resume training on Sunday in the wake of six days spent isolating and six rounds of PCR testing.
With Nienaber still self-isolating, South Africa’s director of rugby Rassie Erasmus has been put in charge of training.
"We’re pleased to be able to name a quality team with a number of experienced players despite the challenges in the last week, which included the entire squad being confined to their rooms as part of the team’s preventative self-isolation measures," Nienaber said.
British and Irish Lions: Watson; Rees-Zammit, Harris, Aki, Adams; Biggar, Murray (captain); Jones, Owens, Sinckler, Itoje, Henderson, Navidi, Curry, Faletau.
Replacements: Cowan-Dickie, Vunipola, Fagerson, Beard, Beirne, Simmonds, Davies, Daly.