Ireland lock Iain Henderson will captain the British and Irish Lions on Wednesday as the tourists take on Cell C Sharks at Emirates Airline Park.
Bundee Aki will also start. Conor Murray is named amongst the replacements along with Tadhg Furlong, Tadhg Beirne and Jack Conan.
Tom Curry, Josh Navidi and Adam Beard will make their first Lions appearances.
The game is the second of eight Tour matches which culminates with three Tests against World Champions, the Springboks.
"It's a quick turnaround from Saturday, but we’ll be ready to go by Wednesday night," said Lions head coach Warren Gatland.
"I’m pleased we managed to come through the weekend’s game unscathed, and the boys have rested and recovered well. We feel like we’re slowly building, but, as ever, there’s still room for improvement in all facets of our game.
"Wednesday night is another chance for us to have a look at a few more combinations. I’m looking forward to seeing how the back row goes; it’s an exciting mixture and one that we hope will offer something a bit different.
"We expect another physical test against a side who are known for their power play and ambition.
"My congratulations to Tom, Josh and Adam ahead of their first starts in a Lions jersey."
Lions team: Liam Williams (Wales); Anthony Watson (England), Elliot Daly (England) Bundee Aki (Ireland), Duhan van der Merwe (Scotland); Dan Biggar (Wales), Gareth Davies (Wales); Mako Vunipola (England), Luke Cowan-Dickie (England), Zander Fagerson (Scotland); Iain Henderson, captain (Ireland), Adam Beard (Wales); Josh Navidi (Wales), Tom Curry (England), Sam Simmonds (England).
Replacements: Ken Owens (Wales), Rory Sutherland (Scotland), Tadhg Furlong (Ireland), Tadhg Beirne (Ireland), Jack Conan (Ireland), Conor Murray (Ireland), Stuart Hogg (Scotland), Chris Harris (Scotland).