Eve Higgins will make her Ireland debut against Wales in Saturday's (kick-off 6pm) Women's Six Nations clash in Cardiff.
Capped 20 times for the Sevens team, Higgins will line out alongside experienced centre Sene Naoupa in midfield.
Uncapped backs Emily Lane and Stacey Flood are included on the replacements bench.
In all there are three changes to the team that lined out in Ireland's last game, the Six Nations win over Italy in October.
Eimear Considine returns to the full-back jersey, with Lauren Delany switching to the right wing and Beibhinn Parsons lining out on the left.
The half-back pairing of Hannah Tyrrell and Kathryn Dane are retained having impressed against the Azzurri.
There is an unchanged front row named by head coach Adam Griggs as Lindsay Peat, Cliodhna Moloney and Linda Djougang once again pack down together, with the fit-again Aoife McDermott returning to the second row alongside Nichola Fryday.
Ciara Griffin leads the side from number eight, with Dorothy Wall set for her fifth cap at blindside flanker and Claire Molloy named at openside.
Lane and Flood provide the half-back cover on the bench, where they are joined by forwards Neve Jones, Katie O'Dwyer, Laura Feely, Brittany Hogan and Hannah O'Connor, with Enya Breen providing the additional backline cover.
Wales lost their opening game 53-0 away to France last weekend.
"We are extremely confident in the squad we have selected," Griggs said.
"We have had a great deal of time to prepare together and this group of players have earned the responsibility to bring the high standards we have set ourselves throughout training into this first game.
"Wales at home will bring a strong challenge and we need to make sure we start the game well and build a platform that allows us to play our game and start this competition off with a win."
Ireland: Eimear Considine; Lauren Delany, Eve Higgins, Sene Naoupu, Beibhinn Parsons; Hannah Tyrrell, Kathryn Dane; Lindsay Peat, Cliodhna Moloney, Linda Djougang; Aoife McDermott, Nichola Fryday; Dorothy Wall, Claire Molloy, Ciara Griffin (capt).
Replacements: Neve Jones, Katie O'Dwyer, Laura Feely, Brittany Hogan, Hannah O'Connor, Emily Lane, Stacey Flood, Enya Breen.
Follow Wales v Ireland (5pm, Saturday) via our live blog on RTE.ie and the RTÉ News app or watch live on RTÉ2 or RTÉ Player, listen live on RTÉ Radio 1's Saturday Sport.