This season's Heineken Champions and Challenge Cup finals will not be played in Marseille as previously scheduled.
The finals of the 2019/20 campaigns were originally due to be held in the French City last year but were moved due to Covid-19 restrictions with the games taking place in Bristol and Aix-en-Provence.
When originally moved from Marseille, it was envisaged that the city would host this year's deciders but that again has been pushed back one year to the 2021/22 finals.
The Tottenham Hotspur Stadium in London will now host the 2022/23 finale.
"After consultation with the relevant local authorities in France and given the evolving public health situation, the Board concluded that in order to reduce cross-border travel where possible and to minimise Covid-19 transmission, flexibility was required regarding the choice of venues for the finals on 21 and 22 May," organisers said.
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"EPCR is working with its shareholder leagues and unions to put in place alternative arrangements for the staging of the two matches with all contingencies underpinned by the primary concern of protecting the health and welfare of players, club staff, match officials, fans, and the wider rugby community.
"The 2022 finals will now be played in Marseille on 27 and 28 May 2022, with European club rugby's blue riband weekend scheduled for London’s Tottenham Hotspur Stadium in 2023."
Tickets already purchased for the Marseille finals will be valid for 2022 and a process is in place for fans seeking refunds which will be communicated directly to ticket holders.
Leinster and Munster and both in Champions Cup last-16 action this weekend, with the newly crowned Guinness Pro14 champions hosting Toulon on Friday night, while Munster face Toulouse at Thomond Park on Saturday.
Should both Irish teams progress they would be away to the winners of Exeter-Lyon and Wasps-Clermont, respectively.
The EPCR also confirmed that teams drawn at home in the Champions Cup semi-finals can play their games at their home venues.
The draw for the competitions' semi-finals takes place on 11 April.
Connacht and Ulster face away ties in the Challenge Cup.
Andy Friend's Connacht are away to Leicester on Saturday, while Dan McFarland's Ulster are at Harlequins the following day.
Follow Leinster v Toulon (5.30pm, Friday) and Munster v Toulouse (3pm, Saturday) in Champions Cup action via our live blogs on RTE.ie and the RTÉ News app or listen live on RTÉ 2fm's Game On and RTÉ Radio 1's Saturday Sport.