Leinster will be without Garry Ringrose, Will Connors and James Ryan for Saturday's Guinness Pro14 final against Munster.
Centre Ringrose will be out for "a number of weeks" because of the injury picked up on duty with Ireland earlier this month.
Ringrose sustained an ankle problem in the win over Scotland and missed the England game.
Lock Ryan is continuing to follow the graduated return to play protocols after a suffering a head injury in the win in Murrayfield.
Flanker Will Connors will be out for eight weeks after suffering a knee injury in Ireland training last week.
Rowan Osborne picked up a fracture to his hand in the game against Ospreys and will undergo surgery this week
However, the news is better on Luke McGrath. The scrum-half has finished his return to play protocols and will train this week
Vakh Abdaladze will increase involvement in team training this week as he continues to recover from a back injury.
Seán Cronin came through the game against Ospreys with no issues after his return from a back injury.
Cian Kelleher (hamstring), Jimmy O’Brien (hamstring), Tommy O’Brien (ankle), Adam Byrne (quad), Caelan Doris (concussion), Dan Leavy (knee), Conor O’Brien (knee) and Max Deegan (knee) remain unavailable.
