England have dropped Elliot Daly to give Max Malins his full-debut in Saturday's Guinness Six Nations clash with France at Twickenham.
Daly has been a mainstay in Eddie Jones' first choice XV since 2016 and has been the preferred full-back since 2018, but his slump in form has resulted in his demotion to the bench with Malins taking over the 15 jersey.
The 28-year-old Saracens star gave an improved performance in the 40-24 defeat by Wales but it was still an error-strewn afternoon and Malins, a specialist full-back who has been in dazzling form on-loan at Bristol, comes in.
A second Lion has been axed by Jones after Jamie George was also named among the replacements, losing his place at hooker to Luke Cowan-Dickie.
The third and final change to the side that effectively surrendered the title at the Principality Stadium sees Charlie Ewels come in for Jonny Hill in the second row.
England: Max Malins; Anthony Watson, Henry Slade, Owen Farrell, Jonny May; George Ford, Ben Youngs; Mako Vunipola, Luke Cowan-Dickie, Kyle Sinckler, Maro Itoje, Charlie Ewels, Mark Wilson, Tom Curry, Billy Vunipola.
Replacements: Jamie George, Ellis Genge, Will Stuart, Jonny Hill, Ben Earl, Dan Robson, Ollie Lawrence, Elliot Daly.
Centre Virimi Vakatawa is back in the starting line-up as France.
Vakatawa, who missed Les Bleus's opening wins against Italy and Ireland with a knee injury, features alongside Gael Fickou while Matthieu Jalibert starts again at flyhalf despite the return of Romain Ntamack from a jaw injury.
Ntamack, who has formed a lethal halfback pair with Antoine Dupont since coach Fabien Galthie took over last year, will be on the bench.
France: Brice Dulin; TeddyThomas, Virimi Vakatawa, Gael Fickou, Damian Penaud; Matthieu Jalibert, Antione Dupont; Gregory Alldritt, Charles Ollivon (capt), Dylan Cretin, Paul Willemse, Romain Taofifenua, Mohamed Haouas, Julien Marchand, Cyril Baille
Replacements: Camille Chat, Jean-Baptiste Gros, Dorian Aldegheri, Cyril Cazeaux, Cameron Woki, Anthony Jelonch, Baptiste Serin, Romain Ntamack
Gloucester scrum-half Stephen Varney will return to the Italy team for Saturday's clash against Wales in Rome.
Varney missed Italy's match with Ireland last month after suffering an injury during the warm-up.
Varney, who was born in Wales but qualifies for Italy through his mother, now returns as one of five changes.
He resumes his half-back partnership with Paolo Garbisi, while wing Mattia Bellini replaces an injured Luca Sperandio.
Elsewhere, switches in the pack see starts for props Danilo Fischetti and Giosue Zilocchi, in addition to lock Niccolo Cannone.
Italy host Wales after suffering comprehensive Six Nations defeats this season against Ireland, France and England, while their last victory in the tournament came six years ago when they toppled Scotland at Murrayfield.
Italy: J Trulla; M Bellini, J-I Brex, C Canna, M Ioane; P Garbisi, S Varney; D Fischetti, L Bigi (capt), G Zilocchi, N Cannone, D Sisi, S Negri, J Meyer, M Lamaro.
Replacements: O Fabiani, A Lovotti, M Riccioni, M Lazzaroni, M Mbanda, M Violi, F Mori, E Padovani.
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