Bundee Aki, Dave Heffernan and Ultan Dillane will start for Connacht against Munster in the Pro14 on Friday night at Thomand Park.
Aki is retained at centre following his release from Ireland duty last weekend, while Heffernan and Dillane both start at hooker and second row respectively.
In all there are seven changes from the side that secured a last-minute win at Treviso.
Denis Buckley comes into an experienced front row with Heffernan and Finlay Bealham, while Gavin Thornbury in in the the second row alongside Dillane.
Conor Oliver starts at openside flanker to face his former club, joining captain Jarrad Butler and Paul Boyle to complete the pack.
There's a new look half-back pairing of Caolin Blade and Jack Carty, while there are also new faces on the wings with Matt Healy and John Porch coming into the starting line-up. 12, 13 and 15 are unchanged from the Benetton win with Aki, Tom Daly and Tiernan O’Halloran all retained.
In all nine of the starting 15 are Connacht centurions as the side look to extend an all-time club record of five straight wins away from home.
Head coach Andy Friend says the importance of the fixture is not lost on the squad.
"We know exactly what we need to do tomorrow night in Limerick. There has been barely any talk of securing Champions Cup qualification because our first objective has always been first place in the Conference B, so all our focus since last weekend has been on getting a win that gives us that fighting chance of a final spot.
"Regarding his team selection, Friend added: "Thankfully we haven’t picked up any major injury worries in our last two games so we’ve a pretty healthy squad apart from our long-term absentees. We’ve named a very experienced starting XV but we’ve made sure to also reward those who showed good form in our last few games. Overall we’re in a positive place and we’re really looking forward to the challenge."
Ahead of the game all Connacht players and management returned negative results in the latest round of PCR testing.
Connacht team: Tiernan O’Halloran, John Porch, Tom Daly, Bundee Aki, Matt Healy, Jack Carty, Caolin Blade
Denis Buckley, Dave Heffernan, Finlay Bealham, Ultan Dillane, Gavin Thornbury, Jarrad Butler, Conor Oliver, Paul Boyle
Replacements: Shane Delahunt, Matthew Burke, Jack Aungier, Niall Murray, Eoghan Masterson, Kieran Marmion, Sean O’Brien, Alex Wootton
Munster have made eight changes for the game in Limerick.
Stephen Archer starts on his 224th appearance for the province and will overtake Marcus Horan to move into fifth place on Munster’s all-time list of record appearance holders.
Billy Holland returns to captain the side.
Academy out-half Ben Healy comes into the side alongside new Ireland cap Craig Casey with the 21-year-olds forming the half-back partnership.
Mike Haley starts at full-back with Andrew Conway and Shane Daly on either flank.
Rory Scannell moves to inside centre with Chris Farrell completing the midfield partnership.
James Cronin, Niall Scannell and Archer pack down in the front row with Fineen Wycherley and Holland in the engine room.
Jack O’Donoghue, Chris Cloete and Munster’s leading try-scorer Gavin Coombes make up the back row.
Joey Carbery is again named among the replacements having made his return from long-term injury off the bench in Cardiff last week.
Munster: Mike Haley; Andrew Conway, Chris Farrell, Rory Scannell, Shane Daly; Ben Healy, Craig Casey; James Cronin, Niall Scannell, Stephen Archer; Fineen Wycherley, Billy Holland (C); Jack O’Donoghue, Chris Cloete, Gavin Coombes.
Replacements: Kevin O’Byrne, Jeremy Loughman, John Ryan, Jean Kleyn, Jack O’Sullivan, Nick McCarthy, Joey Carbery, Damien de Allende.
Follow Munster v Connacht (7.35pm, Friday) and Ulster v Leinster (7.35pm, Saturday) via our live blogs on RTE.ie and the RTÉ News app or listen live on RTÉ Radio 1 Extra and RTÉ Radio 1.