England have suffered a major setback ahead of Saturday's Guinness Six Nations clash with Wales after Courtney Lawes was ruled out by an injury sustained in training.
Lawes was poised to continue at blindside flanker for the Cardiff showdown only to suffer an unspecified injury during Wednesday afternoon's customary full-blooded training session.
The Northampton forward's place in the back row goes to Mark Wilson, who fills the vacancy in the number six jersey after being dropped for the round-two victory over Italy.
The only other change to the XV that routed the Azzurri at Twickenham is Jamie George returning at hooker in place of Luke Cowan-Dickie.
George North will win his 100th Wales cap at the Principality Stadium.
And at 28 years, 320 days, he will eclipse Australia captain Michael Hooper by four weeks as the youngest player to reach a century of caps for their country.
North and Jonathan Davies form Wales' centre pairing, having recovered from foot and ankle injuries respectively, while wing Josh Adams returns after serving a two-match ban for breaching coronavirus protocols.
Elsewhere, Liam Williams moves from wing to full-back, replacing Leigh Halfpenny, Kieran Hardy is preferred to Gareth Davies at scrum-half and flanker Josh Navidi also starts.
Wales: Liam Williams; Louis Rees-Zammit, George North, Jonathan Davies, Josh Adams; Dan Biggar, Kieran Hardy; Wyn Jones, Ken Owens, Tomas Francis, Adam Beard, Alun Wyn Jones (capt), Josh Navidi, Justin Tipuric, Taulupe Faletau.
Replacements: Elliot Dee, Rhodri Jones, Leon Brown, Cory Hill, James Botham, Gareth Davies, Callum Sheedy, Willis Halaholo.
England: Elliott Daly; Anthony Watson, Henry Slade, Owen Farrell, Jonny May; George Ford, Ben Youngs; Mako Vunipola, Jamie George, Kyle Sinckler, Maro Itoje, Jonny Hill, Mark Wilson, Tommy Curry, Billy Vunipola.
Replacements: Luke Cowan-Dickie, Ellis Genge, Wil Stuart, Charlie George Ewels, Ben Martin, Ben Earl, Dan Robson, Max Malins.
Follow Italy v Ireland (kick-off 2.15pm, Saturday) via our live blog on RTE.ie and the RTÉ News app or listen live on RTÉ Radio 1's Saturday Sport. Highlights on Against the Head on RTÉ2 and RTÉ Player.
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