Scotland head coach Gregor Townsend has named his 35-man squad for the 2021 Guinness Six Nations, with Finn Russell returning.
The Racing 92 fly-half injured himself against Wales last November and missed the 2020 Autumn Nations Cup but is included.
Players who could potentially make their Scotland debuts include Edinburgh hooker David Cherry, Sale hooker Ewan Ashman, Gloucester forward Alex Craig and Bath centre Cameron Redpath.
"As coaches we have selected a group which we believe can build on the work our players put in throughout the recent Autumn Nations Cup campaign and kick on again in terms of performance levels," Townsend said.
"The depth we have across the squad enables us to bring in some new players who have excelled in recent weeks and others who we believe can perform at Test level."
The campaign begins with the Calcutta Cup clash against England on Saturday, 6 February.
Townsend said: "Our tournament gets off to a fantastic start with a fixture we look forward to every year against England and the opportunity to win back the Calcutta Cup at Twickenham.
"We are very aware how different this year's competition will be due to the Covid-19 pandemic, but it also provides a huge amount of positivity and enjoyment for millions of supporters and we are looking forward to contesting every match and giving this championship our very best."
Returning to the squad are also Newcastle Falcons back rower Gary Graham, Sale Sharks wing Byron McGuigan, Glasgow Warriors hooker Grant Stewart and London Irish prop Alan Dell.
In the pack, hooker George Turner is selected and joined in the front row by Glasgow team-mates Zander Fagerson and Oli Kebble alongside Edinburgh Rugby representatives WP Nel, Rory Sutherland and Simon Berghan.
Glasgow lock pairing Richie Gray and Scott Cummings and Exeter Chiefs' Jonny Gray are called up along with Edinburgh's Grant Gilchrist, who left the ANC squad with an injury before the opening match.
Hamish Watson and Jamie Ritchie, who have both recently re-signed long-term deals to stay at Edinburgh, are joined as back-row options by Glasgow's Matt Fagerson and Scarlets' Blade Thomson.
Forwards: Ewan Ashman (Sale Sharks), Simon Berghan (Edinburgh), David Cherry (Edinburgh), Alex Craig (Gloucester), Scott Cummings (Glasgow Warriors), Allan Dell (London Irish), Matt Fagerson (Glasgow Warriors), Zander Fagerson (Glasgow Warriors), Gary Graham (Newcastle Falcons), Grant Gilchrist (Edinburgh), Jonny Gray (Exeter Chiefs), Richie Gray (Glasgow Warriors), Oli Kebble (Glasgow Warriors), Willem Nel (Edinburgh), Jamie Ritchie (Edinburgh), Grant Stewart (Glasgow Warriors), Rory Sutherland (Edinburgh), Blade Thomson (Scarlets), George Turner (Glasgow Warriors), Hamish Watson (Edinburgh).
Backs: Darcy Graham (Edinburgh), Chris Harris (Gloucester), Stuart Hogg (Exeter Chiefs), Huw Jones (Glasgow Warriors), Blair Kinghorn (Edinburgh), James Lang (Harlequins), Sean Maitland (Saracens), Byron McGuigan (Sale Sharks), Ali Price (Glasgow Warriors), Cameron Redpath (Bath), Finn Russell (Racing 92), Scott Steele (Harlequins), Duncan Taylor (Saracens), Jaco van der Walt (Edinburgh), Duhan van der Merwe (Edinburgh).
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