Billy Burns and James Lowe have been ruled out of Ireland's Autumn Nations Cup third-place play-off with Scotland through injury, the Irish Rugby Football Union has announced.
Fly-half Burns has not recovered from a groin problem suffered in Sunday's win over Georgia, while winger Lowe will be absent due to a similar issue.
Captain Johnny Sexton and centre Robbie Henshaw should be in contention to play on Saturday having returned to training following their respective hamstring and groin injuries.
Conor Murray's dead leg is being managed and he is expected to be available for selection, while Keith Earls has recovered from a back spasm that affected him during the Georgia game.
Will Connors is proceeding through the graduated return to play protocols but the decision has been made not to target this weekend's fixture.
Prop Ed Byrne will remain out due to an ongoing calf issue, while uncapped duo Harry Byrne and Eric O'Sullivan will train with the squad this week.