Anthony Watson has been ruled out of England's Autumn Nations Cup opener against Georgia because of an ankle injury.
England host Georgia in Group A on 14 November before the visit of Ireland the following week. Ireland play Wales in Dublin on 13 November.
Watson started the 34-5 victory over Italy that clinched the Six Nations title a week ago but the Lions back has been left out of a 36-man training squad to undergo treatment with his club Bath.
George Ford is still troubled by an Achilles issue but he will continue his rehabilitation at England’s Teddington training base.
Uncapped Wasps prospect Jacob Umaga is present as fly-half cover for Owen Farrell in Ford’s absence, although Eddie Jones also sees Henry Slade and George Furbank as options in the position.
England have been boosted by the return of Elliot Daly and Joe Marler, who missed the win in Rome because of respective shin and knee injuries.
Daly’s fitness puts pressure on Furbank at full-back while Marler will challenge Mako Vunipola at loosehead prop.
Number eight Billy Vunipola will join up with the squad on Sunday following the birth of his son earlier this week.