Irish referee Joy Neville will become the first female official to take on Television Match Official duties in a men's international game.
The Limerick native, who refereed the 2017 Women's Rugby World Cup final, will be on TMO duties when Wales face Georgia in the inaugural Autumn Nations Cup tournament on Saturday, 21 November.
She will also be on TMO duties the following week for the match between Scotland and Fiji on 28 November.
"We would like to congratulate Joy on her TMO appointments," said World Rugby chairman Bill Beaumont.
"As part of World Rugby's transformational women’s strategy, we are committed to accelerating development of women in rugby through diversifying and normalising women in leadership positions, both on and off the field.
"Joy, like all the appointed referees, has earned this opportunity and we look forward to watching the referee panel back out officiating the game at the highest level."
Neville was the first female referee to take charge of a Pro14 match in 2018.
Meanwhile, Nigel Owens is in line to become the first referee to officiate 100 test matches when the Welshman takes charge of the fixture between France and Italy at the Autumn Nations Cup.
His first outing of the competition will be England's Twickenham appointment with Georgia on 14 November.
The 49-year-old, who made his test debut in 2003, refereed the 2015 Rugby World Cup final and was an assistant in the 2011 decider.