Ireland international Sammy Arnold and New Zealander Abraham Papali'i will make their Connacht debuts in Sunday's Guinness Pro14 clash with Munster (Aviva Stadium, 3pm).
In all Connacht make 14 changes from the side that saw off Ulster last weekend, with Andy Friend keen to give game-time to more players after a long absence due to Covid-19.
Ex-Bay of Plenty number 8 Papali'i forms a back row with Conor Oliver and Eoghan Masterson, who is the only player retained from last week.
Quinn Roux captains the side having recovered from injury to take his place in the second row alongside Niall Murray, with Paddy McAllister, Shane Delahunt and Dominic Robertson-McCoy completing the pack.
Sunday’s half-back pairing consists of Caolin Blade and Conor Fitzgerald, while Arnold will be partnered in the centre by Tom Daly.
The experienced Tiernan O’Halloran and Matt Healy are included in the back three, while there’s also a first appearance for Colm de Buitléar since January 2019.
The winger from Carraroe played four times during 2018/19 while in the Connacht Academy, but hasn’t featured since suffering a serious achilles injury in the 2019/20 pre-season.
Connacht: Tiernan O'Halloran, Colm de Buitléar, Sammy Arnold, Tom Daly, Matt Healy, Conor Fitzgerald, Caolin Blade; Paddy McAllister, Shane Delahunt, Dominic Robertson-McCoy, Niall Murray, Quinn Roux (capt), Eoghan Masterson, Conor Oliver, Abraham Papali’i.
Replacements: Jonny Murphy, Conor Kenny, Matthew Burke, Ultan Dillane, Seán Masterson, Stephen Kerins, Peter Robb, Conor Dean.
Tadhg Beirne is in line to make his first Munster appearance since sustaining an ankle fracture away to Saracens in December.
The Ireland lock is among five players coming into the pack from the side that was beaten by Leinster last Saturday.
Jeremy Loughman, John Ryan, Fineen Wycherley and Chris Cloete are all drafted into the side.
Shane Daly starts at full-back with last week's try-scorers Andrew Conway and Keith Earls on either flank.
Damian de Allende and Chris Farrell pair up in the centres for the second time with Conor Murray and JJ Hanrahan in the half-backs.
Loughman, Niall Scannell and Ryan pack down in the front row with Wycherley and Beirne starting in the engine room together for the first time.
Captain Peter O'Mahony, Cloete and CJ Stander complete the starting XV.
A win will secure Munster's place in the semi-finals.
Munster: Shane Daly; Andrew Conway, Chris Farrell, Damian de Allende, Keith Earls; JJ Hanrahan, Conor Murray; Jeremy Loughman, Niall Scannell, John Ryan; Fineen Wycherley, Tadhg Beirne; Peter O'Mahony (C), Chris Cloete, CJ Stander.
Replacements: Kevin O’Byrne, Liam O’Connor, Stephen Archer, Billy Holland, Jack O’Donoghue, Craig Casey, Rory Scannell, Jack O’Sullivan.
Follow Ulster v Leinster (7.35pm, Saturday) and Munster v Connacht (3pm, Sunday) via our live blogs on RTÉ.ie/sport and the News Now app, or listen to live commentary on RTÉ Radio 1.