England's final Guinness Six Nations match against Italy in Rome on 14 March has been postponed due to the spread of coronavirus.
Tournament organisers faced the option of playing the game behind closed doors at the Stadio Olimpico or delaying it until later in the year and have chosen the latter option.
Shaping the decision is the Italian Rugby Federation's desire to retain the revenue generated by a lucrative home clash with Eddie Jones' title hopefuls.
By staging the game behind closed doors, the cash-strapped union would have missed out on gate receipts for a 73,000 sell-out.
It is the second game of the 2020 Six Nations to be postponed after Ireland's clash with Italy in Dublin on Saturday was also called off on public health grounds.
The Women's Six Nations game, due to be played on 15 March in Padua, is also postponed.
The decision comes after an Italian government decree issued on Wednesday night said Serie A matches would not be open to the public until 3 April at the earliest in an attempt to halt the spread of Covid-19.
Italy is the European country most affected by the coronavirus with in excess of 3,000 people infected - a number that includes over 100 deaths. Eleven towns in northern Italy are in lockdown.
Six Nations organisers are being guided by government directives in deciding the fate of games and in light of the decree, activated their contingency plan to find a new date for games affected by the virus.
Six Nations chiefs now face the challenge of finding a date to restage England's visit to Rome, knowing there is not much room in the calendar to accommodate the match.
The postponements mean it will be some time before a winner of the 2020 Six Nations is established.
England face Wales at Twickenham on Saturday needing victory to keep them in title contention.