England's final Guinness Six Nations match against Italy at the Stadio Olimpico will either be played behind closed doors or postponed due to the outbreak of the coronavirus.
It comes after an Italian government decree released on Wednesday night said all sporting events in the country would not be open to the public until 3 April in an attempt to halt the spread of Covid-19.
Sources at the Italian Rugby Federation and Italian Olympic Committee have confirmed to the PA news agency that England's climax to the Championship, originally scheduled for 14 March, could now be replayed at a later date.
Six Nations organisers are being guided by government directives and, in light of the decree, they will discuss the fate of the game with the English and Italian unions on Thursday.
Rearranging the fixture will be difficult due to the packed rugby calendar and the need to secure player releases from Gallagher Premiership clubs, but the IRF will also be reluctant to lose the revenue generated by a lucrative home clash with Eddie Jones' title hopefuls.
Ireland are also due to play France on 14 March. Their scheduled game against Italy in Dublin this weekend was called off over a week ago.
A statement on www.governo.it read: "There will be no sporting events with the presence of the public in order to prevent further contagion opportunities."
"The provisions of this decree are effective from the date of publication until April 3, 2020."
Serie A fixtures will also be affected, while the Coppa Italia semi-final between Napoli and Inter Milan, scheduled for Thursday evening, was postponed earlier on Wednesday.
Juventus are also scheduled to play Lyon on March 17 in Turin in the second leg of their Champions League last-16 tie.
Italy is the European country most affected by coronavirus, with more than 3,000 people infected - a number which includes over 100 deaths. Eleven towns in northern Italy are in lockdown.