Josh Adams has been ruled out of Wales' remaining Six Nations games against England and Scotland.
Adams, who has scored 10 tries in his last 10 Tests, suffered an ankle injury during Wales' 27-23 loss to France on Saturday.
And the Welsh Rugby Union confirmed the wing will miss the remainder of the tournament, adding that he is due to have surgery this week.
The WRU said in a statement: "Josh Adams will play no further part in Wales' 2020 Guinness Six Nations campaign following an ankle injury sustained in the match against France.
"He is due to have surgery this week and it is envisaged that he could return in 12 weeks for the latter stages of the Guinness PRO14.
"No-one has been added to the squad."
It is a huge blow to Wales head coach Wayne Pivac, given Adams' sustained excellence that also saw him finish as top tryscorer at the Rugby World Cup.
He has claimed 14 touchdowns in his 24-cap Test career and been unquestionably Wales' most potent attacking weapon during the last year.
Adams' fellow wing George North also went off in the France game, his departure following an aerial collision with Gael Fickou.
North failed a head injury assessment and is set to follow graduated return-to-play protocols.
