Saracens centre Nick Tompkins will make his first Wales start in Saturday's Guinness Six Nations clash against Ireland.
Tompkins, who delivered a try-scoring debut off the bench when Wales beat Italy 42-0 five days ago, partners Hadleigh Parkes in midfield.
George North, a centre starter against the Azzurri, moves back to his familar wing position, replacing Johnny McNicholl.
Wales head coach Wayne Pivac has made no other changes to the starting line-up.
Switches among the replacements, though, see McNicholl being joined by prop Rhys Carre, who is available again after serving a suspension following his sending off in Saracens' Champions Cup victory over the Ospreys last month.
Scrum-half Gareth Davies and Gloucester back Owen Williams are also on the bench, together with Ospreys lock Adam Beard, who replaces an injured Cory Hill.
Wales: Leigh Halfpenny, George North, Nick Tompkins, Hadleigh Parkes, Josh Adams, Dan Biggar, Tomos Williams, Taulupe Faletau, Justin Tipuric, Aaron Wainwright, Alun Wyn Jones (captain), Jake Ball, Dillon Lewis, Ken Owens, Wyn Jones.
Replacements: Ryan Elias, Rhys Carre, Leon Brown, Adam Beard, Ross Moriarty, Gareth Davies, Owen williams, Johnny McNicholl.
Follow Ireland v Wales (kick-off 2.15pm) on Saturday via our live blog on RTE.ie/Sport and the News Now app or listen live on RTÉ Radio 1's Saturday Sport. Highlights on Against the Head, Monday at 8pm on RTÉ2 and RTÉ Player.
