England coach Eddie Jones included eight uncapped players but retained the bulk of his World Cup group when he named a 34-man squad for the Six Nations championship.
Jones included 22 players involved in Japan, where England lost in the final to South Africa, but many of the absentees are carrying injuries, including number eight Billy Vunipola, who broke his arm for the fourth time on Sunday.
Prop Dan Cole, who had a torrid time in the final against the Springboks, was an expected omission, while versatile back Jack Nowell was also missing, though Jones, who will hold a news conference later on Monday, might reveal an injury concern.
Of the uncapped group, Tom Dunn, Ben Earl and Ollie Thorley have been involved in previous squads, while Fraser Dingwall, George Furbank, Alex Moon, Will Stuart and Jacob Umaga are called up for the first time.
In addition to the 34 players, Josh Hodge, who plays in the second tier Championship, and Alex Mitchell have been called up as apprentices and will only train with the squad.
England open their campaign away to France on Sunday, 2 February.
Luke Cowan-Dickie (Exeter Chiefs, 21 caps), Tom Curry (Sale Sharks, 19 caps), Tom Dunn (Bath, uncapped), Ben Earl (Saracens, uncapped), Charlie Ewels (Bath Rugby, 12 caps), Ellis Genge (Leicester Tigers, 14 caps), Jamie George (Saracens, 45 caps), Ted Hill (Worcester Warriors, 1 cap), Maro Itoje (Saracens, 34 caps), George Kruis (Saracens, 41 caps), Joe Launchbury (Wasps, 62 caps), Courtney Lawes (Northampton Saints, 81 caps), Lewis Ludlam (Northampton Saints, 6 caps), Joe Marler (Harlequins, 68 caps), Alex Moon (Northampton Saints, uncapped), Kyle Sinckler (Harlequins, 31 caps), Will Stuart (Bath Rugby, uncapped), Sam Underhill (Bath Rugby, 15 caps), Mako Vunipola (Saracens, 58 caps), Harry Williams (Exeter Chiefs, 18 caps)
Elliot Daly (Saracens, 39 caps), Ollie Devoto (Exeter Chiefs, 1 cap), Fraser Dingwall (Northampton Saints, uncapped), Owen Farrell (Saracens, 79 caps), George Ford (Leicester Tigers, 65 caps), George Furbank (Northampton Saints, uncapped), Willi Heinz (Gloucester Rugby, 9 caps), Jonathan Joseph (Bath Rugby, 47 caps), Jonny May (Leicester Tigers, 52 caps), Ollie Thorley (Gloucester Rugby, uncapped), Manu Tuilagi (Leicester Tigers, 40 caps), Jacob Umaga (Wasps, uncapped), Anthony Watson (Bath Rugby, 42 caps), Ben Youngs (Leicester Tigers, 95 caps)