Ireland international Jack Carty will start at full-back for Connacht in their Heineken Champions Cup clash with Gloucester on Saturday (12.45pm).
Carty is part of a back three that includes Niyi Adeolokun and John Porch on the wings.
Conor Fitzgerald and Caolin Blade also renew their half-back partnership while Bundee Aki and Kyle Godwin start in midfield.
In the forwards, captain Jarrad Butler will make his 50th appearance in a Connacht jersey.
The openside is named in a backrow that includes the returning Eoin McKeon at blindside and Paul Boyle at number 8.
Having played all 80 minutes in his last three outings, lock Quinn Roux steps out so Ultan Dillane and Joe Maksymiw are named to start in the second row.
20-year-old academy player Niall Murray is included among the replacements for the first time.
In the front row Dave Heffernan comes back in at hooker with Peter McCabe and Dominic Robertson-McCoy at loosehead and tighthead respectively.
Connacht: Jack Carty, Niyi Adeolokun, Kyle Godwin, Bundee Aki, John Porch, Conor Fitzgerald, Caolin Blade; Peter McCabe, Dave Heffernan, Dominic Robertson McCoy, Ultan Dillane, Joe Maksymiw, Eoin McKeon, Jarrad Butler (capt), Paul Boyle.
Replacements: Shane Delahunt, Denis Buckley, Finlay Bealham, Niall Murray, Eoghan Masterson, Stephen Kerins, Tom Daly, Robin Copeland.
Follow all the weekend's Champions Cup action with RTÉ Sport Online and the RTÉ News Now app and listen to live coverage of Leinster v Northampton on RTÉ Radio 1's Saturday Sport.
🍒 TEAM NEWS— Gloucester Rugby (@gloucesterrugby) December 13, 2019
Gloucester Rugby make several changes for the trip to Galway to face @connachtrugby in Round 4 of @ChampionsCup @LewisLudlow94
captains the side on Saturday afternoon.
Proudly sponsored by @BPE_Solicitors#CONvGLO pic.twitter.com/0JWN868T00