Stephen Archer makes his 200th club appearance in the Pro14 clash against Edinburgh in Cork as the prop becomes just the 11th Munster man to reach the landmark.
Head coach Johann van Graan has handed academy prospect Ben Healy his first league start at out-half.
The former Nenagh Ormond and Glenstal Abbey player was a grand slam winner with the Ireland Under-20s last season and plays his All Ireland League rugby with Garryowen.
Jack O'Donoghue captains the side and is the only player retained from last week's thrilling Champions Cup draw against Racing 92 with 11 of the starting XV products of the Greencore Munster Rugby Academy.
Shane Daly starts at full-back with Calvin Nash and Alex Wootton named on either flank.
Dan Goggin and Sammy Arnold partner up in the centres with Nick McCarthy in the half-backs alongside Healy.
Liam O’Connor, Rhys Marshall and Archer pack down in the front row with Fineen Wycherley and Darren O’Shea in the engine room.
O’Donoghue, Tommy O’Donnell and Arno Botha complete the side.
Munster: Shane Daly; Calvin Nash, Sammy Arnold, Dan Goggin, Alex Wootton; Ben Healy, Nick McCarthy; Liam O’Connor, Rhys Marshall, Stephen Archer; Fineen Wycherley, Darren O’Shea; Jack O’Donoghue (capt) Tommy O’Donnell, Arno Botha
Replacements: Kevin O’Byrne, James Cronin, Keynan Knox, Jed Holloway, Conor Oliver, Neil Cronin, JJ Hanrahan, Rory Scannell
