Scott Fardy will captain Leinster in their Pro14 clash against the Ospreys at the RDS on Friday (kick-off 7.35pm) while scrum-half Rowan Osborne is in line to make his debut and James Lowe returns from injury.
Head coach Leo Cullen has made a number of changes to the team that accounted for Benetton Rugby away in Treviso in Round 1.
It's a new back three with Hugo Keenan starting at full-back, Fergus McFadden on the right wing and James Lowe returning from injury for his first game since the Pro14 final triumph in May.
It's as you were in the centre and in the half backs though with Joe Tomane and Rory O'Loughlin again at 12 and 13, and Jamison Gibson-Park and Ross Byrne at scrumhalf and outhalf.
Peter Dooley, Rónan Kelleher and Michael Bent continue in the front row, with one change in the second row as skipper Fardy comes in alongside Devin Toner.
The back row also has one change with Josh Murphy starting this week at blindside flanker, with Will Connors at openside and Caelan Doris again at number eight.
On the bench Michael Milne and Harry Byrne are in line to make their first appearance at the RDS Arena after their debuts last weekend, while Dublin University FC's Rowan Osborne is due to make his senior debut having impressed in the pre-season friendly against Coventry and over the last number of weeks for Leinster 'A' in the Celtic Cup.
Osborne, who plays at scrum half for Trinity in the Energia All-Ireland League, has played for Ireland Students and the Ireland U18 Schools team during his time at Clongowes Wood College.
Leinster: Hugo Keenan; Fergus McFadden, Rory O'Loughlin, Joe Tomane, James Lowe; Ross Byrne, Jamison Gibson-Park; Peter Dooley, Rónan Kelleher, Michael Bent; Devin Toner, Scott Fardy (Capt); Josh Murphy, Will Connors, Caelan Doris.
Replacements: James Tracy, Michael Milne, Vakh Abdaladze, Ross Molony, Max Deegan, Rowan Osborne, Harry Byrne, Conor O’Brien.