Ulster's South African loose-forward Marcell Coetzee is out of the Rugby World Cup after it was confirmed he will undergo ankle surgery on Wednesday that will sideline him for 12 weeks.
Coetzee was replaced after 17 minutes of Saturday's 24-18 World Cup warm-up victory over Argentina in Pretoria but coach Rassie Erasmus said he was hopeful the Ulster back-rower would be available when he names his 31-man squad on Aug. 26.
The Boks are already without number eight Warren Whiteley through injury, and must now find a back-up to the influential Duane Vermeulen, with Francois Louw having played at the back of the scrum this season as well.
The Boks have also released four players for domestic Currie Cup duty at the weekend, which suggests they will struggle to make the final World Cup squad as the team continue to prepare this week in Bloemfontein.
They are props Lizo Gqoboka and Thomas du Toit, lock Marvin Orie and centre Andre Esterhuizen.
South Africa open their World Cup campaign against New Zealand in Yokohama on 21 September. They have also been pooled with Italy, Namibia and Canada.